Abstract
Chronic HBV infection is a major cause of hepatocellular carcinoma (HCC) which meanwhile has become the 5th most reason for a fatal outcome of cancer. Worldwide, approximately 350 million people are chronically HBV infected and as such of risk to develop HCC, of those an estimated high rate of children. Treatment of chronic infection is sufficient to reduce the rate of HCC but the rate of sustained virological response remains to low, not at least due to emergence of resistant virus strains. Less is known on HBV infection in children despite the extremely high rate of chronicity. The case of a nine years old male with a 6 year history of chronic HBV infection, of those 5 years with antiviral treatment is described. Before our lab was consulted, the patient was unsuccessfully treated with interferon, an obscure drug named Hepon, which should activate antiviral immune response, and Lamivudine, the latter most likely becoming ineffective due to the mergence of resistant subpopulations (rtL180 M, rtV207 M, two strains with stop codons at position rt188 and rt198, rtM204V (YVDD), rtM204K (YKDD)). Replacement of Lamivudine by adefovir displayed no advantage despite the lack of resistance mutations, thus no decrease in viremia was obs...Continue Reading
References
Jan 4, 1997·Lancet·M M BartholomewN A Brown
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M I AllenL D Condreay
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J L DienstagN Brown
Oct 21, 1999·The New England Journal of Medicine·J L DienstagN A Brown
Mar 7, 2001·Gastroenterology·E Doo, T J Liang
Oct 2, 2002·Journal of Clinical Microbiology·Anna S F LokErwin Sablon
Aug 2, 2003·Gastroenterology·Peter AngusStephen Locarnini
Mar 5, 2004·Journal of Viral Hepatitis·D Lavanchy
Dec 4, 2004·AIDS·Oliver SchildgenJürgen Kurt Rockstroh
May 6, 2005·Journal of Clinical Microbiology·B ZöllnerH-H Feucht
Apr 28, 2006·The New England Journal of Medicine·Oliver SchildgenWolfram H Gerlich
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H HoofnagleAnna S F Lok
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokUNKNOWN Hepatitis B Virus Drug Resistance Working Group
Citations
Sep 24, 2013·Virology Journal·Mingshun ZhangZuhu Huang
Feb 24, 2011·Virology Journal·Pan ZhaoQun Guan
Mar 4, 2014·PloS One·Yan LiuDongping Xu
Aug 19, 2014·Journal of Viral Hepatitis·Y LiuD Xu
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hakan AlagozluMahmut Coskun
Mar 27, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cecilia M DelfinoMirna M Biglione
Mar 15, 2019·Bioscience Reports·Wenxuan LiuFengxue Yu