PMID: 9535164Apr 16, 1998Paper

Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of nerve insensitivity resistance to pyrethroids in Heliothine lepidoptera

Insect Molecular Biology
D J HeadA Callaghan

Abstract

Coding sequences from the intracellular segment linking repeat domains III and IV of the para-homologous sodium channel gene were amplified and cloned from two species of Heliothine larvae using RT-PCR techniques. Sequence comparisons between standard laboratory susceptible and nerve insensitive strains of the tobacco budworm (Heliothis virescens) and the cotton bollworm (Helicoverpa armigera) identified two mutations. These were an aspartic acid (GAC) to valine (GTC) and a glutamic acid (GAA) to glycine (GGA) mutation. PCR and sequencing was undertaken only on individuals that were demonstrated to be phenotypically nerve insensitive or susceptible to pyrethroids using a neurophysiological technique. The finding of identical mutations across two species suggests that they may be implicated in resistance.

Citations

May 29, 2003·Insect Biochemistry and Molecular Biology·D M Soderlund, D C Knipple
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christopher M JonesCraig S Wilding
Sep 11, 2013·Pesticide Biochemistry and Physiology·Frank D RinkevichKe Dong
Jul 21, 2004·Insect Biochemistry and Molecular Biology·Y YangG D Moores
Apr 2, 2015·PloS One·Malal M DiopCédric Pennetier
Mar 19, 2019·Journal of Agricultural and Food Chemistry·Zi-Guo WangXue-Qing Yang

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