Novel nanocomposite of nano fe(3)o(4) and polylactide nanofibers for application in drug uptake and induction of cell death of leukemia cancer cells

Langmuir : the ACS Journal of Surfaces and Colloids
Gang LvZhongze Gu

Abstract

Novel nanocomposites of polylactide (PLA) nanofibers and tetraheptylammonium-capped Fe3O4 magnetic nanoparticles have been prepared and utilized to realize the efficient accumulation of anticancer drug daunorubicin in target cancer cells. The observations of optical microscopy and confocal fluorescence microscopy indicate that the PLA nanofibers and Fe3O4 nanoparticles may contribute to their beneficial effects on intracellular drug uptake of leukemia K562 cell lines in which the efficiently enhanced accumulation of anticancer drug daunorubicin on the membrane of cancer cells could be observed. Meanwhile, the electrochemical detection and the microculture tetrazolium studies were also explored to probe the effect of the relevant nanomaterials on the drug uptake of cancer cells. The results illustrate that the nanocomposites could effectively facilitate the interaction of daunorubicin with leukemia cells and remarkably enhance the permeation and drug uptake of anticancer agents in the cancer cells, which could readily lead to the induction of the cell death of leukemia cells. This observation suggests a new perspective for the targeted therapeutic approaches of cancers.

References

Mar 20, 2003·Journal of the American Chemical Society·Yossi WeizmannItamar Willner
Nov 13, 2003·Chembiochem : a European Journal of Chemical Biology·Guo-Rui HuangJia-Rui Wu

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Citations

Jan 6, 2012·Chemical Reviews·Morteza MahmoudiAlke Petri-Fink
Nov 11, 2008·International Journal of Nanomedicine·Bao-An ChenNing-Na Chen
Jul 13, 2011·International Journal of Molecular Sciences·Juan L Vivero-Escoto, Yu-Tzu Huang
Sep 25, 2015·Colloids and Surfaces. B, Biointerfaces·Pedro P G GuimarãesRubén D Sinisterra
Jul 19, 2016·Advanced Drug Delivery Reviews·Betty TylerHenry Brem
Dec 7, 2017·Advanced Healthcare Materials·Shixuan ChenJingwei Xie
Feb 6, 2021·International Journal of Pharmaceutics·Črt DragarPetra Kocbek

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