Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases

Current Pharmaceutical Design
Javier O MoralesMarcelo J Kogan

Abstract

Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions, smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases are depicted.

Citations

May 18, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Yu-Wen WuThierry Burnouf
Apr 1, 2017·Therapeutic Delivery·Mariacristina Gagliardi
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga PechanovaMartina Cebova

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