Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta

Chemical & Pharmaceutical Bulletin
S AokiM Kobayashi

Abstract

Two novel aplysinopsin-type indole alkaloids, 1 and 2, and three known indole alkaloids were isolated from the marine sponge Hyrtios erecta. These compounds exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase (nNOS). Furthermore, new quinolone 7 was also isolated from the same marine sponge. The chemical structures of these new compounds were elucidated on the basis of spectroscopic analysis.

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Citations

Feb 4, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Kalimuthu Senthilkumar, Se-Kwon Kim
Jul 15, 2009·Marine Drugs·Dobroslawa Bialonska, Jordan K Zjawiony
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May 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nourhan Hisham ShadyUsama Ramadan Abdelmohsen
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Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulrahman M AlahdalSameh S Elhady
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May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Jan 26, 2020·The Journal of Pharmacy and Pharmacology·Raphael de Mello CarpesIsrael Felzenszwalb
Jul 23, 2020·Pharmaceutical Biology·Ahreum HongSang-Jip Nam
Jun 24, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Guo-Fei WangCai-Guo Huang
Mar 30, 2013·Marine Drugs·Diaa T A YoussefHani Z Asfour
Oct 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Samman MunirMohsin Khurshid
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Apr 11, 2013·Organic Letters·Rei MomoseJun'ichi Kobayashi
Dec 28, 2006·Journal of Natural Products·Pierre SauleauMarie-Lise Bourguet-Kondracki

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