PMID: 8959743Jan 1, 1996Paper

Novel neuropeptide Y processing in human cerebrospinal fluid from depressed patients

Peptides
R EkmanC E Costello

Abstract

In vitro processing of neuropeptide Y (NPY) in cerebrospinal fluid (CSF) of patients with depression was monitored by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Single peptide bonds in NPY were cleaved to yield N- or C-terminal fragments. Multiple cleavage to form internal peptides was unimportant. Degradation rates varied between individuals, whereas the product distributions were fairly constant. Other peptides did not evidence such proteolysis. MALDI-TOF MS will facilitate extensive investigations of NPY processing that could provide the basis for clinical assays and illuminate the pathophysiology related to depression.

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Citations

Jun 11, 1998·Peptides·C L NilssonR Ekman
Apr 20, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A WestrinL Träskman-Bendz
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·K E WilsonC M Morris
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R W GardenJ V Sweedler
Sep 1, 2004·Neuropeptides·Markus Heilig
May 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Caterina ProtoAntonio Lanzone
Aug 4, 2015·Dento Maxillo Facial Radiology·Juste Armalaite, Kristina Lopatiene
Aug 22, 2017·Frontiers in Endocrinology·Annika Thorsell, Aleksander A Mathé

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