Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population

Inflammatory Bowel Diseases
Georgia E HumeGraham L Radford-Smith

Abstract

The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic, debilitating disorder. These include the Toll-like receptors, specifically TLR4 and TLR5. A variant in the TLR4 gene (A299G) has demonstrated variable association with CD. We aimed to investigate the relationship between TLR4 A299G and TLR5 N392ST, and an Australian inflammatory bowel disease cohort, and to explore the strength of association between TLR4 A299G and CD using global meta-analysis. Cases (CD = 619, ulcerative colitis = 300) and controls (n = 360) were genotyped for TLR4 A299G, TLR5 N392ST, and the 4 major NOD2 mutations. Data were interrogated for case-control analysis prior to and after stratification by NOD2 genotype. Genotype-phenotype relationships were also sought. Meta-analysis was conducted via RevMan. The TLR4 A299G variant allele showed a significant association with CD compared to controls (P = 0.04) and a novel NOD2 haplotype was identified which strengthened this (P = 0.003). Furthermore, we identified that TLR4 A299G was associated with CD limited to the colon (P = 0.02). In the presence of the novel NOD2 haplotype, ...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jun 3, 2000·Nature Genetics·N C ArbourD A Schwartz
Jan 7, 2003·The Journal of Biological Chemistry·Naohiro InoharaGabriel Nuñez
Apr 3, 2003·Gastroenterology·Tadakazu HisamatsuDaniel K Podolsky
Apr 8, 2004·The Journal of Pediatrics·Maria T Abreu, Moshe Arditi
Mar 17, 2005·World Journal of Gastroenterology : WJG·Peter Laszlo LakatosUNKNOWN Hungarian IBD Study Group
May 21, 2005·Inflammatory Bowel Diseases·Liekele E OostenbrugPeter L M Jansen
Jul 13, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Henri BraatDaan Hommes

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Citations

May 17, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Andrei E Medvedev
May 21, 2009·Annual Review of Genomics and Human Genetics·Johan Van LimbergenJack Satsangi
Dec 15, 2012·World Journal of Gastroenterology : WJG·Lan ChenXiao-Ping Lv
May 28, 2010·The International Journal of Neuroscience·Mei YuanQidong Yang
Feb 12, 2010·Expert Opinion on Therapeutic Targets·Pedro Pimentel-NunesAdelino F Leite-Moreira
Jun 13, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Noha Ahmed Nasef, Lynnette R Ferguson
Sep 15, 2009·Seminars in Immunology·Masayuki FukataMaria T Abreu
Oct 31, 2012·The British Journal of Dermatology·A SavvaE J Giamarellos-Bourboulis
Jun 4, 2010·International Journal of Immunogenetics·E Garza-GonzálezF J Bosques-Padilla
Jul 18, 2015·Autoimmunity Reviews·Elena Gianchecchi, Alessandra Fierabracci
Dec 11, 2014·BMC Gastroenterology·Nezha SenhajiSellama Nadifi
Apr 25, 2016·Digestive Diseases and Sciences·Yolanda F M TolentinoHeitor S de Souza
Jul 8, 2017·Pharmacogenomics·Sara RufiniPaola Borgiani
Jul 21, 2010·Inflammatory Bowel Diseases·Paul HendersonDavid C Wilson
Feb 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Si Ming ManHazel M Mitchell
Nov 27, 2008·The American Journal of Gastroenterology·Guillaume Savoye, Eric Lerebours
Mar 13, 2014·Nature Reviews. Gastroenterology & Hepatology·Johan Van LimbergenJack Satsangi
Apr 9, 2020·Journal of Pediatric Gastroenterology and Nutrition·Tracy CoelhoSarah Ennis
May 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·Tracy CoelhoSarah Ennis
Aug 25, 2012·Digestive Diseases and Sciences·Anastassios C ManolakisSpyros P Potamianos

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