PMID: 8585989Nov 1, 1995Paper

Novel nuclear ribonucleoprotein structural components in the dormouse adrenal cortex during hibernation

Chromosoma
M MalatestaS Fagan

Abstract

Adrenocortical cell nuclei of the dormouse Muscardinus avellanarius were investigated by electron microscopic immunocytochemistry in hibernating, arousing and euthermic individuals. While the basic structural constituents of the cell nucleus did not significantly modify in the three groups, novel structural components were found in nuclei of hibernating dormice. Lattice-like bodies (LBs), clustered granules (CGs), fibrogranular material (FGM) and granules associated with bundles of nucleoplasmic fibrils (NF) all contained ribonucleoproteins (RNPs), as shown by labeling with anti-snRNP (small nuclear RNP), anti-m3G-capped RNA and anti-hnRNP (heterogeneous nuclear RNP) antibodies. Moreover, the FGM also showed immunoreactivity for the proliferation associated nuclear antigen (PANA) and the non-snRNP splicing factor SC-35. All these nuclear structural components disappeared early during arousal and were not found in euthermic animals. These novel RNP-containing structures, which have not been observed in other tissues investigated so far in the same animal model, could represent storage and/or processing sites for pre-mRNA during the extreme metabolic condition of hibernation, to be quickly released upon arousal. NFs, which had be...Continue Reading

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Citations

Dec 1, 1996·Histochemistry and Cell Biology·M TamburiniS Fakan
Oct 20, 2005·Histochemistry and Cell Biology·Lorella VecchioMarco Biggiogera
Jan 18, 2006·Histochemistry and Cell Biology·Beatrice BaldelliManuela Malatesta
Aug 11, 2000·Molecular and Cellular Biology·J E KnightB B Boyer
Sep 29, 2004·Microscopy Research and Technique·Beatrice BaldelliManuela Malatesta
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C ZancanaroS Fakan
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Biggiogera, C Pellicciari
Mar 30, 1999·The Anatomical Record·M MalatestaG Gazzanelli
May 3, 2014·Cell Stress & Chaperones·Shannon N Tessier, Kenneth B Storey
Apr 5, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·WenWen WuYuji Aiyoshi

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