Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor (ATBF1) Gene

Asian-Australasian Journal of Animal Sciences
Xiaoyan ZhangXianyong Lan

Abstract

The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammalian growth and development. The goal of this study was to detect novel nucleotide variations and haplotypes structure of the ATBF1 gene, as well as to test their associations with growth-related traits in goats. Herein, a total of seven novel single nucleotide polymorphisms (SNPs) (SNP 1-7) within this gene were found in two well-known Chinese native goat breeds. Haplotypes structure analysis demonstrated that there were four haplotypes in Hainan black goat while seventeen haplotypes in Xinong Saanen dairy goat, and both breeds only shared one haplotype (hap1). Association testing revealed that the SNP2, SNP5, SNP6, and SNP7 loci were also found to significantly associate with growth-related traits in goats, respectively. Moreover, one diplotype in Xinong Saanen dairy goats significantly linked to growth related traits. These preliminary f...Continue Reading

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Citations

Jun 15, 2019·Animal Biotechnology·Shaoli ZhangXianyong Lan
Apr 17, 2020·Animals : an Open Access Journal From MDPI·Libang HeLei Qu
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Zhenyu WeiXianyong Lan

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SHEsis
PopGene
Primer Premier
SPSS

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