Novel optical assessments of tissue composition and viability using fluorescence spectroscopy and tissue oxygenation spectrophotometry in patients with systemic sclerosis: a pilot study

Physiological Measurement
John AllenBridget Griffiths

Abstract

Patients with systemic sclerosis (SSc) experience significant morbidity and mortality, therefore, the development of tests to aid its early diagnosis are very important. The aim of this pilot study was to assess the diagnostic value of novel optical non-invasive skin fluorescence spectroscopy (FS) and tissue oxygen saturation (TOS) viability measurements in patients with established SSc. Two groups were studied, comprising 14 SSc patients and nine healthy controls (93% and 73% females, respectively). FS and TOS measurements were collected from three body sites: the forearm, chest, and calf. Fluorescence intensities at wavelengths attributed to collagen, elastin, and L-tryptophan were computed, with adjustment for melanin, and a normalised combined fluorescence score (NCFS) was determined. The NCFS was significantly higher (p  <  0.001) and the combined TOS significantly lower (p  <  0.001) in the SSc group. TOS measurements alone showed good classification accuracy (95.7%) at separating SSc from healthy control participants, with some clustering of values close to the 50% oxygenation level in both groups. When the composition and viability measures were combined and modelled using binary logistic regression, excellent results f...Continue Reading

References

Jan 1, 1996·Advances in Experimental Medicine and Biology·D K HarrisonA S Jain
Jan 1, 1997·Advances in Experimental Medicine and Biology·D J NewtonP T McCollum
Feb 24, 2001·Journal of Clinical Laser Medicine & Surgery·J TangR R Alfano
Jan 5, 2002·Arthritis and Rheumatism·V D Steen, T A Medsger
Sep 6, 2002·Pigment Cell Research·Jennifer K WagnerMark D Shriver
Nov 25, 2003·Photochemistry and Photobiology·Ralph S DaCostaBrian C Wilson
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Christopher P DentonDavid J Abraham
Dec 29, 2006·Diabetes Care·Robbert MeerwaldtAndries J Smit
Aug 13, 2010·Nature Reviews. Rheumatology·Maurizio CutoloVanessa Smith
Feb 22, 2013·Annals of the Rheumatic Diseases·Giuseppina AbignanoFrancesco Del Galdo

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