Novel papillomavirus isolated from the oral mucosa of a polar bear does not cluster with other papillomaviruses of carnivores

Veterinary Microbiology
Hans StevensM Van Ranst

Abstract

Papillomatosis has been documented in several carnivores, and papillomavirus (PV) types have been characterized from lesions in a number of carnivore species: the canine oral PV (COPV), the Felis domesticus PV type 1 (FdPV-1) isolated from a Persian cat, the Procyon lotor PV type 1 (PlPV-1) isolated from a raccoon, the canine PV type 2 (CPV-2) from a dog's foot pad lesion and the canine PV type 3 (CPV-3) associated with a canine epidermodysplasia verruciformis - like disease. A tissue sample was taken from a papillomatous lesion on the oral mucosa of a polar bear (Ursus maritimus). Extracted DNA was used as a template for multiply primed rolling-circle amplification (RCA), and restriction enzyme analysis of the RCA product indicated the presence of papillomaviral DNA. The genome of this PV was cloned and the complete genomic sequence was determined. The Ursus maritimus PV type 1 (UmPV-1) genome counts 7582 basepairs and is smaller than that of other papillomaviruses from carnivore species. UmPV-1 contains the typical noncoding region NCR1, but unlike the carnivore PVs of the Lambda genus, UmPV-1 does not possess a second noncoding region NCR2. Phylogenetic analysis based on a nucleotide sequence alignment of the L1 ORF of UmPV-...Continue Reading

References

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Apr 14, 2007·Genome Biology·Annabel RectorMarc Van Ranst

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Citations

Sep 14, 2011·Virology Journal·Christian E LangeKurt Tobler
Feb 6, 2016·BMC Evolutionary Biology·Beatriz Mengual-ChuliáIgnacio G Bravo
Mar 14, 2013·Veterinary Microbiology·Raquel García-PérezIgnacio G Bravo
Apr 21, 2009·Trends in Microbiology·Reimar JohneHans Stevens
Oct 24, 2015·Veterinary Microbiology·Jacqueline Mazzuchelli-de-SouzaClaudia E Thompson
May 29, 2013·Virology·Scott B Vande Pol, Aloysius J Klingelhutz
Jan 5, 2011·Molecular Phylogenetics and Evolution·Marc GottschlingIngo Nindl
Mar 9, 2010·Virology·Hans-Ulrich BernardEthel-Michele de Villiers
Jun 5, 2013·Virology·Ann Roman, Karl Munger
May 29, 2013·Virology·Annabel Rector, Marc Van Ranst
Dec 1, 2017·Viruses·Aayushi Uberoi, Paul F Lambert
Aug 7, 2017·Microbiome·Wen ZhangEric Delwart
Feb 16, 2018·Veterinary Research Communications·Daniel A TruchadoLaura Benítez

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