Novel patch-based systems for the localised delivery of ALA-esters

Journal of Photochemistry and Photobiology. B, Biology
Desmond I J MorrowRyan F Donnelly

Abstract

In photodynamic therapy (PDT) a combination of visible light and a sensitising drug causes the destruction of selected cells. Aminolaevulinic acid (ALA) has been widely used in topical PDT for over 15 years. However, ALA does not possess favourable physicochemical properties for skin penetration. Consequently, the clearance rates for difficult to treat lesions, such as nodular basal cell carcinomas are relatively low. For the first time, equimolar concentrations of ALA, methyl-ALA (m-ALA) and hexyl-ALA (h-ALA) have been incorporated into a bioadhesive patch-based system. In vitro penetration studies into excised porcine skin revealed that ALA patches containing relatively high loadings (226.7 micromol cm(-2)) were associated with significantly greater tissue concentrations (70.7 micromol cm(-3)) than patches containing m-ALA (16.3 micromol cm(-3)) or h-ALA (17.4 micromol cm(-3)). ALA was also found to be the most efficient inducer of protoporphyrin (PpIX) fluorescence in mice, in vivo (maximum mean fluorescence: ALA=236.2 a.u., m-ALA=175.1 a.u., h-ALA=193.5 a.u.). However, when the lipophilic hexylester was formulated in a pressure sensitive adhesive (PSA) patch, significantly higher PpIX levels were achieved compared to all bi...Continue Reading

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Citations

Aug 9, 2013·International Journal of Nanomedicine·Lei ShiHongwei Wang
Oct 8, 2014·Photodiagnosis and Photodynamic Therapy·Mary-Carmel KearneyRyan F Donnelly
Jan 4, 2012·The British Journal of Dermatology·A Hauschild
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Mar 17, 2017·International Journal of Biological Macromolecules·Aqdas NoreenKhalid Mahmood Zia
Jan 15, 2014·Advanced Healthcare Materials·Anthony P RaphaelTarl W Prow
Nov 11, 2020·Dermatologic Therapy·Erika Valentina De LucaKetty Peris
Oct 8, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Annunziata DattolaMaria C Fargnoli

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