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Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

bioRxiv

Nov 9, 2019

Kevin HadiMarcin Imielinski

Abstract

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be trivially classified into simple (e.g. deletion, translocation) or complex (e.g. chromothripsis, chromoplexy) structural variant classes. Applying a genome graph computational paradigm t...read more

Mentioned in this Paper

Genome
DNA Repair
Cutaneous Melanoma
Neoplasms
Copying (Learning)
Esophageal
Gene Deletion
Chromothripsis
Ovarian Carcinoma
Adenocarcinoma
163
39
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Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

bioRxiv

Nov 9, 2019

Kevin HadiMarcin Imielinski

DOI: 10.1101/836296

Abstract

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be trivially classified into simple (e.g. deletion, translocation) or complex (e.g. chromothripsis, chromoplexy) structural variant classes. Applying a genome graph computational paradigm t...read more

Mentioned in this Paper

Genome
DNA Repair
Cutaneous Melanoma
Neoplasms
Copying (Learning)
Esophageal
Gene Deletion
Chromothripsis
Ovarian Carcinoma
Adenocarcinoma
163
39

Similar Papers Found In These Feeds

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Related Papers

bioRxiv

Patterns of structural variation in human cancer

bioRxivAugust 27, 2017
Yilong LiPeter Campbell
Trends in Cancer

Deciphering the Code of the Cancer Genome: Mechanisms of Chromosome Rearrangement

Trends in CancerJanuary 5, 2016
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Paper Details
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