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Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

bioRxiv

Nov 9, 2019

Kevin HadiMarcin B Imielinski

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Abstract

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be trivially classified into simple (e.g. deletion, translocation) or complex (e.g. chromothripsis, chromoplexy) structural variant classes. Applying a genome graph computational paradigm t...read more

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Adenocarcinoma
Breast
DNA Repair
Gene Deletion
Gene Rearrangement
Genome
Neoplasms
Ovarian Carcinoma
Cutaneous Melanoma
Acral
162
31
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Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

bioRxiv

Nov 9, 2019

Kevin HadiMarcin B Imielinski

DOI: 10.1101/836296

Abstract

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be trivially classified into simple (e.g. deletion, translocation) or complex (e.g. chromothripsis, chromoplexy) structural variant classes. Applying a genome graph computational paradigm t...read more

Mentioned in this Paper

Adenocarcinoma
Breast
DNA Repair
Gene Deletion
Gene Rearrangement
162
31

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Paper Details
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