Novel percutaneous adventitial drug delivery system for regional vascular treatment

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Fumiaki IkenoMehrdad Rezaee

Abstract

A novel intracoronary microsyringe system (MicroSyringe) was developed for regulated drug injection into the adventitial space. In this report, the feasibility, safety, and distribution pattern of vascular treatment with this modality were tested in 17 swine by delivering Oregon green-labeled paclitaxel (OGP) and tacrolimus. Coronaries were harvested 0.5-96 hr postinjection and analyzed for drug by fluorescence histochemistry (OGP) and liquid chromatography-mass spectrometry (tacrolimus). Histopathological analysis was subsequently performed. The microsyringe deliveries were performed safely in all cases. In the OGP-injected group, within 2 hr postprocedure there was intense staining of the adventitia, media, and endothelium around the injection site, and by 23 hr staining extended distally by 27.5 mm. With tacrolimus, similar longitudinal drug distribution was seen; furthermore, by 48 hr there was detectable drug over 40 mm proximal and distal to the injection site. Significant levels of tacrolimus were detectable in coronaries at 96 hr. Percutaneous adventitial delivery is safe, feasible, and provides consistent dosing for complete treatment of a vascular territory.

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Citations

Jun 1, 2012·Journal of Cardiovascular Translational Research·Niall G Campbell, Ken Suzuki
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Warren ShermanTomasz Siminiak
Oct 10, 2009·Circulation Research·Rajesh GuptaDouglas W Losordo
Oct 18, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Wen TianSigrid Nikol
Jul 16, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Ju LeeWonHyoung Ryu
Sep 30, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Alexander S YevzlinBryan N Becker
Aug 25, 2005·Medical Hypotheses·Anthony J YunPatrick Y Lee
May 29, 2015·Bioconjugate Chemistry·Ellen M Cahill, Eoin D O'Cearbhaill
Aug 9, 2016·Pharmacology & Therapeutics·Philipp WörsdörferSüleyman Ergün
Apr 5, 2017·Photochemistry and Photobiology·Stefano ProttiAlexander Greer
Aug 1, 2021·Journal of Materials Science. Materials in Medicine·Rupali S Bhadale, Vaishali Y Londhe

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