Novel pH-responsive tobramycin-embedded micelles in nanostructured multilayer-coatings of chitosan/heparin with efficient and sustained antibacterial properties

Materials Science & Engineering. C, Materials for Biological Applications
Wenhao ZhouYufeng Zheng

Abstract

To endow orthopaedic implants with satisfactory antibacterial properties, the design and development of antibiotic coating on the surface of implants is highly desired. In this work a novel and facile strategy was developed to form pH-responsive layer-by-layer (LbL) films implanted with polymeric micelles as nano-vehicles loaded with charge-weak antibiotic drugs, enabling high drug loading efficiency. Negatively charged tobramycin (Tob)-embeded heparin miscells (HET) and positively charged chitosan (CHT) were exploited as a pH-responsive LBL multilayer building block, respectively. The formation mechanism and pH-stimulated release behavior of the Tob-contained heparin micelles were studied. The characterization on the morphologies, chemical compositions and hydrophilicity of the modified surface confirmed the successuful deposition of the Tob-loaded CHT/HET multilayers coatings on the polydopamine-modified Ti surface. The drug release profiles displayed fast release at pH 7.4 and slow release after exposure to weakly acidic environments. Antibacterial tests indicated that the Tob-embed CHT/HET nanostructured multilayers not only strongly inhibited initial bacterial adhesion, but also disruptted biofilm formation. Particularly, ...Continue Reading

Citations

Aug 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nikita DevnarainThirumala Govender
Dec 12, 2018·Advanced Materials·Xingshu LiXi Zhang
Aug 24, 2018·Journal of Functional Biomaterials·Ludovica ParisiGuido M Macaluso
Jan 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Anqi LiJianshu Li
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Tzu-Wen HuangFwu-Long Mi
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jianqiao LiuYujin Tang
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Clara I ColinoCarmen Gutierrez-Millan

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