Novel pharmacological approaches to the treatment of type 2 diabetes

Pharmacological Reviews
E J Verspohl


The huge increase in type 2 diabetes is a burden worldwide. Many marketed compounds do not address relevant aspects of the disease; they may already compensate for defects in insulin secretion and insulin action, but loss of secreting cells (β-cell destruction), hyperglucagonemia, gastric emptying, enzyme activation/inhibition in insulin-sensitive cells, substitution or antagonizing of physiological hormones and pathways, finally leading to secondary complications of diabetes, are not sufficiently addressed. In addition, side effects for established therapies such as hypoglycemias and weight gain have to be diminished. At present, nearly 1000 compounds have been described, and approximately 180 of these are going to be developed (already in clinical studies), some of them directly influencing enzyme activity, influencing pathophysiological pathways, and some using G-protein-coupled receptors. In addition, immunological approaches and antisense strategies are going to be developed. Many compounds are derived from physiological compounds (hormones) aiming at improving their kinetics and selectivity, and others are chemical compounds that were obtained by screening for a newly identified target in the physiological or pathophysiol...Continue Reading


Feb 1, 1979·Diabetologia·Werner Creutzfeldt
Jan 1, 1992·Rheumatology International·A KumarR Kakkar
Oct 1, 1992·Southern Medical Journal·V HarisdangkulA C Lin
Jul 1, 1992·Diabetes/metabolism Reviews·Werner Creutzfeldt, M Nauck
Jul 1, 1991·Journal of Cellular Biochemistry·J L BednarczykB W McIntyre
Mar 27, 1990·European Journal of Pharmacology·E J VerspohlG Lambrecht
Jun 1, 1990·Diabetes Care·Luciano RossettiRalph DeFronzo
Jan 1, 1986·Diabetes/metabolism Reviews·M D Meglasson, Franz M Matschinsky
Sep 1, 1988·Regulatory Peptides·C Erlanson-Albertsson, A Larsson
Oct 1, 1987·The Journal of Clinical Investigation·Luciano RossettiRalph DeFronzo
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M A NauckWerner Creutzfeldt
May 1, 1987·The Journal of Clinical Investigation·Luciano RossettiRalph DeFronzo
Jan 1, 1987·Renal Failure·I A SimpsonI Hutton
Jan 1, 1986·Hemoglobin·H J LiD S Xie
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A StarkeRoger H Unger
Jun 24, 1968·Biochimica Et Biophysica Acta·J H KinoshitaKenneth H Gabbay
Jan 1, 1966·Histochemie. Histochemistry. Histochimie·V K Hopsu-Havu, G G Glenner
Jul 1, 1995·Bioorganic & Medicinal Chemistry·M C ViaudG Guillaumet
Jan 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J F CaroG L Dohm
Apr 1, 1993·Digestive Diseases and Sciences·A WettergrenJ J Holst
Mar 15, 1993·Annals of the New York Academy of Sciences·G A Bray
Jul 1, 1996·Diabetes·Ann Marie SchmidtD Stern
Dec 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·A NicolucciA Liberati
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J FlintN K Tonks
Sep 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H JijakliWilly J Malaisse
Jun 1, 1997·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C H ChenR C Rogers
Mar 21, 1998·The Journal of Clinical Investigation·A FlintJ J Holst
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·W H MartinJ L Treadway
May 29, 1998·The Journal of Clinical Investigation·T ForstAndreas Pfützner
Oct 2, 1998·British Journal of Pharmacology·A Pelé-TounianAlain Ktorza
Oct 29, 1998·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·T ForstJohn Wahren
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·I Karydis, G Tolis
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E NäslundP M Hellström
Jul 22, 1999·The New England Journal of Medicine·Peter R Shepherd, B B Kahn
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·R N CortrightG L Dohm
Apr 28, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·Bo-Lennart JohanssonJohn Wahren
Jun 13, 2000·Advances in Experimental Medicine and Biology·Ingrid de MeesterSimon Scharpé
Aug 29, 2000·Diabetes Research and Clinical Practice·N KatoSoroku Yagihashi
Dec 29, 2000·Diabetes Care·S E GeerlingsDiabetes Women Asymptomatic Bacteriuria Utrecht Study Group
Jan 3, 2001·American Journal of Physiology. Renal Physiology·E M Wright
Jan 5, 2001·Expert Opinion on Investigational Drugs·Peter J Oates, B L Mylari
Feb 13, 2001·Biochemical and Biophysical Research Communications·W J Ryves, A J Harwood
Feb 22, 2001·Methods : a Companion to Methods in Enzymology·B F BakerB Monia
Mar 27, 2001·Bioorganic & Medicinal Chemistry Letters·D G SmithR W Ward
Apr 3, 2001·Current Pharmaceutical Design·A S Wagman, J M Nuss
Jun 27, 2001·Bioorganic & Medicinal Chemistry Letters·T M TagmoseJ B Hansen
Jul 27, 2001·Current Opinion in Chemical Biology·Z Y Zhang
Sep 19, 2001·The Journal of Biological Chemistry·M NakamuraT W Gardner
Sep 21, 2001·The Biochemical Journal·S Frame, P Cohen
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hyo Chol HaSolomon H Snyder
Mar 2, 2002·The Journal of Organic Chemistry·Andrzej R DaniewskiGeorge P Yiannikouros
Mar 7, 2002·Trends in Molecular Medicine·Hagit Eldar-Finkelman
Jun 5, 2002·FEBS Letters·Shigeki TakedaShigeki Mitaku
Jun 21, 2002·Australian Veterinary Journal·S M JaenschK Wyatt
Aug 9, 2002·Nature·Rachel L BatterhamStephen R Bloom
Aug 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bradley A ZinkerMichael R Jirousek
Aug 30, 2002·International Review of Neurobiology·Peter J Oates
Sep 5, 2002·Nature Reviews. Drug Discovery·Theodore O JohnsonMichael R Jirousek
Dec 12, 2002·Diabetes·Suad EfendicS V Zaitsev
Jan 23, 2003·Seminars in Perinatology·Krishna G PeriSylvain Chemtob
Feb 6, 2003·The British Journal of Nutrition·I Stuart Wood, Paul Trayhurn
Feb 7, 2003·Current Medicinal Chemistry·Garry J Southan, Csaba Szabó
Mar 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Batya PlotkinHagit Eldar-Finkelman
Mar 18, 2003·Diabetes Research and Clinical Practice·Kazuma MiwaNigishi Hotta
Apr 5, 2003·Advances in Experimental Medicine and Biology·Ingrid de MeesterSimon Scharpé
May 15, 2003·Chemical Reviews·Xiaolong ChenYinchu Shen
May 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stacey L ConarelloBei B Zhang
Jun 12, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bo-Lennart JohanssonJohn Pernow
Jun 26, 2003·Bioorganic & Medicinal Chemistry Letters·Koji OhsumiNobuo Kondo
Jul 11, 2003·Bioorganic & Medicinal Chemistry Letters·Yi Sup ShimHyeongjin Cho
Jul 19, 2003·Science·Joseph GrimsbyJoseph F Grippo
Jul 23, 2003·Current Medicinal Chemistry·Gang Liu
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·Tim KarlStephan von Hörsten
Sep 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Christian ThorkildsenJørgen Søberg Petersen
Oct 1, 1964·The Journal of Clinical Endocrinology and Metabolism·H ELRICKY ARAI
Sep 25, 2003·Journal of Cellular Biochemistry·Lubing ZhouKeith T Demarest
Oct 8, 2003·Annals of Surgery·Philip R SchauerDavid Kelley
Oct 22, 2003·Archives of Biochemistry and Biophysics·Paul J Thornalley
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·René SanterDan Klaerke
Nov 19, 2003·Nitric Oxide : Biology and Chemistry·Thomas WallerathUlrich Förstermann
Dec 20, 2003·American Journal of Nephrology·W Kline BoltonACTION I Investigator Group
Jan 30, 2004·Annual Review of Medicine·Stanley T Crooke
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Peter A Campochiaro, C99-PKC412-003 Study Group
Mar 27, 2004·Lancet·E A M GaleEuropean Nicotinamide Diabetes Intervention Trial (ENDIT) Group
Apr 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Christophe BrocaMohammed Taouis
Apr 23, 2004·Trends in Biochemical Sciences·Richard S Jope, Gail V W Johnson
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Bo AhrénA Schweizer
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathrin MaedlerMarc Y Donath
May 20, 2004·Bioorganic & Medicinal Chemistry Letters·Han-Cheng ZhangBruce E Maryanoff
Aug 5, 2004·Pharmaceutical Research·Barry I Hudson, Ann Marie Schmidt
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Aug 6, 2004·Endocrine Reviews·Andrea M VincentEva L Feldman
Sep 11, 2004·Bioorganic & Medicinal Chemistry Letters·Roger LégerDominique P Bridon
Nov 10, 2004·Medical Hypotheses·Mark F McCarty
Nov 17, 2004·Current Medicinal Chemistry·Tomoichiro AsanoYasunobu Uchijima
Dec 1, 2004·Basic & Clinical Pharmacology & Toxicology·Jesper GromadaPatrik Rorsman
Dec 21, 2004·Biochemical and Biophysical Research Communications·Takatoshi SogaKiyoshi Furuichi
Dec 29, 2004·Diabetes Research and Clinical Practice·Nessar Ahmed
Dec 30, 2004·Diabetes/metabolism Research and Reviews·Joel R L EhrenkranzJesse Roth
Jan 19, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Jens J Holst
Mar 17, 2005·Bioconjugate Chemistry·Sang-Heon LeeKang Choon Lee
Mar 23, 2005·Regulatory Peptides·Werner Creutzfeldt
Mar 23, 2005·Regulatory Peptides·M A Nauck, J J Meier
Mar 26, 2005·Protein Engineering, Design & Selection : PEDS·Kin-Ming LoStephen D Gillies
Apr 7, 2005·The Annals of Pharmacotherapy·Jaime A Davidson
May 3, 2005·Diabetologia·H Kolb, Thomas Mandrup-Poulsen
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
May 28, 2005·Endocrinology·Alexander M EfanovJesper Gromada
Jun 1, 2005·Biochemical Pharmacology·Douglas L FeinsteinC Dello Russo
Jun 4, 2005·Biotechnology Progress·Xiaolong ChenYinchu Shen
Jun 4, 2005·Phytotherapy Research : PTR·E J VerspohlEckhard Neddermann
Jun 14, 2005·Biochimica Et Biophysica Acta·Wilhelm Stahl, Helmut Sies
Jul 23, 2005·Annals of the New York Academy of Sciences·Ryuichi Wada, Soroku Yagihashi
Jul 23, 2005·Annals of the New York Academy of Sciences·Paul A Voziyan, Billy G Hudson
Jul 28, 2005·Diabetes·Bart Staels, Jean-Charles Fruchart
Aug 24, 2005·Drugs·Jacqueline D Reeves, Andrew J Piefer
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Charlotte StrømMichael Larsen
Sep 28, 2005·Journal of Cellular Biochemistry·Irving G JoshuaSuresh C Tyagi
Oct 4, 2005·Bioorganic & Medicinal Chemistry Letters·Xiaoyan ZhangKeith T Demarest
Oct 6, 2005·The International Journal of Biochemistry & Cell Biology·Diva D De LeónDoris A Stoffers
Oct 20, 2005·American Journal of Physiology. Endocrinology and Metabolism·Line Mariann GrønningPeter R Shepherd
Dec 15, 2005·Australasian Radiology·R P LimB M Tress
Dec 29, 2005·Bioorganic & Medicinal Chemistry Letters·Xiaoyan ZhangKeith T Demarest
Jan 18, 2006·Annual Review of Medicine·Laurie L Baggio, D J Drucker
Jan 31, 2006·Diabetes Care·Paul S Denker, Paul E Dimarco
Feb 7, 2006·Current Medicinal Chemistry·Xiaolong ChenYinchu Shen
Feb 24, 2006·International Journal of Clinical Practice·A J Krentz, P S Friedmann
Mar 1, 2006·Bioorganic & Medicinal Chemistry Letters·Darren McKerrecherRolf P Walker
Jun 22, 2006·Current Medicinal Chemistry·Kevin R Guertin, Joseph Grimsby
Jun 29, 2006·Diabetes·Dorothy ZelentFranz M Matschinsky
Aug 11, 2006·Physiology & Behavior·Barry E Levin
Aug 22, 2006·British Journal of Pharmacology·G J CoopeBrendan Leighton
Oct 6, 2006·The Journal of Pharmacology and Experimental Therapeutics·M J StevensIrina G Obrosova
Oct 14, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M A NauckNN2211-1499 Study Group
Oct 24, 2006·Nature Clinical Practice. Neurology·Gina M LeinningerEva L Feldman
Nov 17, 2006·Regulatory Peptides·Lene HansenJens J Holst
Nov 23, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·Brian R Walker
Dec 1, 2006·The New England Journal of Medicine·Renata BelfortKenneth Cusi
Dec 8, 2006·Annals of the New York Academy of Sciences·Dan Ziegler
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Meng-Ju LiuHee-Sook Jun
Jan 9, 2007·Journal of Neuroinflammation·Marvin BorisDouglas L Feinstein
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Desu ChenMing-Wei Wang
Jan 12, 2007·Biochemical and Biophysical Research Communications·Erik FlodgrenAlbert Salehi
Jan 16, 2007·Journal of Internal Medicine·E M WrightD F Loo
Jan 17, 2007·Diabetologia·L LuziA Caumo
Apr 3, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·A BhatiaR Nijhawan
Apr 7, 2007·Diabetologia·Matthew C T FyfePhilippe Wong-Kai-In
Apr 13, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarManjeet Singh
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Y Donath
Apr 25, 2007·Bioorganic & Medicinal Chemistry Letters·Gang ZhaoPhilip R Kym
May 15, 2007·Gastroenterology·Laurie L Baggio, D J Drucker
Jun 19, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Net Das Evcimen, George L King
Aug 4, 2007·Kidney International. Supplement·Melinda T CoughlanMark E Cooper
Sep 29, 2007·Pharmacology & Therapeutics·Maria Sörhede Winzell, Bo Ahrén
Oct 9, 2007·Diabetes, Obesity & Metabolism·S BavamianP Meda
Nov 27, 2007·British Journal of Pharmacology·H A OvertonC Reynet
Dec 6, 2007·The American Journal of Cardiology·Jean-Charles Fruchart
Dec 7, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Brian D Green, Peter R Flatt
Jan 1, 2008·Regulatory Peptides·Nis B PedersenJens J Holst
Jan 22, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marialaura AmadioAlessia Pascale
Jan 24, 2008·JAMA : the Journal of the American Medical Association·John B DixonMargaret Anderson
Jan 29, 2008·Current Drug Targets·Peter J Oates
Jan 31, 2008·Expert Opinion on Investigational Drugs·Matthew Coghlan, Brendan Leighton
Feb 12, 2008·TheScientificWorldJournal·Jennifer L Wilkinson-Berka, Antonia G Miller
Feb 19, 2008·Cellular and Molecular Life Sciences : CMLS·I I ZaitsevaS V Zaitsev
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Koh AmanoHisashi Narimatsu
Mar 7, 2008·The Journal of Biological Chemistry·Tao PangJia Li
Mar 12, 2008·Bioorganic & Medicinal Chemistry Letters·Scott D EdmondsonAnn E Weber
Mar 20, 2008·Experimental Diabetes Research·Karin Ekberg, Bo-Lennart Johansson
Mar 28, 2008·Expert Opinion on Investigational Drugs·Katherine A HughesBrian R Walker
Mar 28, 2008·Expert Opinion on Investigational Drugs·Nick Giannoukakis
Apr 12, 2008·World Journal of Pediatrics : WJP·Bao-Sheng Yu, An-Ru Wang
Apr 17, 2008·British Journal of Pharmacology·Monica Montagnani
Apr 22, 2008·Diabetes, Obesity & Metabolism·B F BurkeyJ E Foley
Apr 23, 2008·Endocrinology·L LaufferP L Brubaker
Apr 26, 2008·Journal of Receptor and Signal Transduction Research·Dinesh GautamJürgen Wess
May 2, 2008·Pharmacotherapy·Mary Ann Ramirez, Nancy L Borja
May 31, 2008·Diabetes·Josephine M ForbesMark E Cooper
Jun 19, 2008·Bioorganic & Medicinal Chemistry Letters·Unmesh ShahJean E Lachowicz
Jun 28, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Felix Kratz
Jun 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Roberto VettorLucia Frittitta
Jul 12, 2008·Pharmacology & Therapeutics·James L EdwardsEva L Feldman
Jul 25, 2008·The Biochemical Journal·Loranne Agius
Jul 26, 2008·Reviews in Endocrine & Metabolic Disorders·Sally A Madsen-Bouterse, Renu A Kowluru
Aug 14, 2008·Journal of Medicinal Chemistry·Graeme SempleRobert M Jones
Sep 5, 2008·Current Opinion in Neurology·Douglas W Zochodne
Sep 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sherley VisinoniSofianos Andrikopoulos
Sep 17, 2008·Biochemical Society Transactions·Ruth BrownlieDavid M Smith
Sep 17, 2008·Biochemical Society Transactions·Anath Shalev
Oct 3, 2008·The Journal of Clinical Investigation·Risto KerkelaGordon S Huggins
Oct 16, 2008·Current Pharmaceutical Biotechnology·Toshinari TakamuraShuichi Kaneko
Oct 22, 2008·Journal of Clinical Pharmacology·Shashank RohatagiDaniel E Salazar
Oct 22, 2008·Bioorganic & Medicinal Chemistry Letters·Luc J FarmerFrancesco G Salituro
Nov 11, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Dec 3, 2008·Expert Opinion on Emerging Drugs·Quresh Mohamed, Tien Y Wong
Dec 11, 2008·Vascular Health and Risk Management·Bernd RichterChristian Lerch
Dec 17, 2008·Current Topics in Medicinal Chemistry·Joseph GrimsbyRamakanth Sarabu
Dec 24, 2008·Biochemical and Biophysical Research Communications·Guo-qing ZhuangYan He
Dec 26, 2008·Diabetes Research and Clinical Practice·S ChearskulW Nitiyanant
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dean R ArtisJames F Tobin
Jan 8, 2009·Diabetes, Obesity & Metabolism·Iskandar Idris, Richard Donnelly
Jan 9, 2009·Clinical Pharmacology and Therapeutics·B KomoroskiM Pfister
Jan 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Angana Gupta RajapakseZhihong Yang
Jan 20, 2009·Current Medicinal Chemistry·Maria Assunta PotenzaMonica Montagnani
Jan 29, 2009·The Journal of Clinical Endocrinology and Metabolism·Bo AhrénJ E Foley
Feb 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana González-PérizJoan Clària
Feb 18, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SchirraB Göke
Feb 21, 2009·Advances in Experimental Medicine and Biology·Lina Nordquist, Sara Stridh
Feb 25, 2009·Expert Opinion on Drug Safety·C V RizosE N Liberopoulos
Feb 27, 2009·Expert Opinion on Investigational Drugs·Mark Kipnes
Feb 27, 2009·Clinical Science·Claire E Hills, Nigel J Brunskill
Apr 18, 2009·Nature Reviews. Drug Discovery·Franz M Matschinsky
May 6, 2009·Journal of Cellular Biochemistry·Tomohiko YoshidaPaula H Stern
May 12, 2009·Cellular and Molecular Life Sciences : CMLS·Arne C RuferMichael Hennig
May 16, 2009·Nature Reviews. Endocrinology·Julie A Lovshin, D J Drucker
May 22, 2009·Expert Opinion on Therapeutic Patents·Craig D Boyle, Timothy J Kowalski
May 29, 2009·Bioorganic & Medicinal Chemistry Letters·Michael SiuJennifer E Vogel
Jun 23, 2009·Diabetes Care·Claus M LarsenThomas Mandrup-Poulsen
Jun 24, 2009·Nephron. Clinical Practice·B R Conway, A P Maxwell
Jun 26, 2009·Expert Opinion on Therapeutic Patents·Jeffrey W Corbett
Jun 30, 2009·Biopharmaceutics & Drug Disposition·Holger FuchsAndreas Greischel
Jul 9, 2009·The Annals of Pharmacotherapy·Amie McCord Brooks, Stacey M Thacker
Aug 13, 2009·Journal of Atherosclerosis and Thrombosis·Hiroshi TakataYoshio Terada
Sep 4, 2009·Bioorganic & Medicinal Chemistry Letters·Tomoharu IinoTeruyuki Nishimura
Sep 8, 2009·Diabetes, Obesity & Metabolism·A Leone-BayP Richardson
Sep 9, 2009·Expert Opinion on Pharmacotherapy·Vincent C Woo
Sep 15, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Nigel Irwin, Peter R Flatt
Sep 29, 2009·Expert Opinion on Therapeutic Patents·Robert M JonesJuerg Lehmann
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Irina G Obrosova
Oct 13, 2009·Diabetes, Obesity & Metabolism·M A KebedeV Poitout
Oct 13, 2009·European Journal of Pharmacology·Guy A HigginsMalik Slassi
Oct 27, 2009·Expert Opinion on Therapeutic Patents·William N Washburn
Oct 27, 2009·Bioorganic & Medicinal Chemistry Letters·Tomomichi ChonanAkira Hiratate
Nov 7, 2009·The Journal of Clinical Endocrinology and Metabolism·Sunil Nair, John P H Wilding
Nov 17, 2009·Nature Biotechnology·Volker SchellenbergerWillem P C Stemmer
Jan 2, 2010·FEBS Letters·Thomas A KnappeMohamed A Marahiel
Jan 12, 2010·Metabolic Syndrome and Related Disorders·S SchwartzSukumar Nagendran
Jan 21, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Stefan BlechKlaus Wagner
Feb 9, 2010·Bioorganic & Medicinal Chemistry Letters·Michael ArnostJeremy Green
Feb 20, 2010·The Journal of Pharmacology and Experimental Therapeutics·Dahlia Doughty-ShentonPatrick J Casey
Feb 23, 2010·Bioorganic & Medicinal Chemistry Letters·Wensheng YuGuowei Zhou
Feb 26, 2010·Current Topics in Medicinal Chemistry·Li-Fang YuJia Li
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·May-yun WangRoger H Unger
Mar 27, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Q ZhangF-Z Song
Apr 27, 2010·Diabetes, Obesity & Metabolism·Vivian FonsecaBart Staels
Apr 28, 2010·Expert Review of Neurotherapeutics·Jesús AvilaFélix Hernández
Apr 28, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ji Young ParkKwang-Won Kim
Apr 29, 2010·Current Diabetes Reports·Anupa K Patel, Vivian Fonseca
Apr 29, 2010·Current Diabetes Reports·Mikkel Christensen, Filip K Knop
May 22, 2010·Diabetologia·J Rungby
May 27, 2010·Diabetes/metabolism Research and Reviews·Wolfgang GlaesnerTom Bumol
May 29, 2010·Nature Reviews. Drug Discovery·Edward C Chao, Robert R Henry
Jun 4, 2010·Orvosi hetilap·Gábor Winkler, Péter Kempler
Jun 8, 2010·Journal of Receptor and Signal Transduction Research·M SiebelmannE J Verspohl
Jun 12, 2010·Bioorganic & Medicinal Chemistry Letters·Tomomichi ChonanAkira Hiratate
Jul 2, 2010·Diabetes, Obesity & Metabolism·André J Scheen
Jul 22, 2010·American Journal of Physiology. Endocrinology and Metabolism·Wei GuMurielle M Véniant
Jul 24, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Ron J KeizerAlwin D R Huitema
Aug 10, 2010·Clinical Pharmacokinetics·André J Scheen
Aug 17, 2010·Acta Pharmacologica Sinica·Bok Hee Choi, Sang June Hahn
Aug 18, 2010·Diabetologia·K MüssigA Fritsche
Oct 28, 2010·The Annals of Pharmacotherapy·Jessica L KerrKatherine A Petkewicz
Nov 26, 2010·Bioorganic & Medicinal Chemistry Letters·Vinay M GirijavallabhanShelby Umland
Dec 1, 2010·Diabetes, Obesity & Metabolism·G Hollis, R Huber
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Linda P C YuLiang Tong
Dec 15, 2010·Bioorganic & Medicinal Chemistry Letters·Dong-Ming ShenE R Parmee
Apr 8, 2011·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S G TerraR A Calle
Apr 9, 2011·New Biotechnology·Bianca Ahrens
Apr 26, 2011·Bioorganic & Medicinal Chemistry Letters·Kurt G PikeIngrid Wilson
May 13, 2011·Trends in Endocrinology and Metabolism : TEM·Allison J Richard, Jacqueline M Stephens
Jun 30, 2011·Diabetes Technology & Therapeutics·Riccardo Perfetti
Aug 16, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·M D BensonB Kluve-Beckerman
Nov 1, 2009·Expert Review of Clinical Pharmacology·Ronald Christopher, Aziz Karim
Nov 29, 2011·Bioorganic & Medicinal Chemistry Letters·Kevin J FilipskiAngel Guzman-Perez
Jul 20, 2012·Journal of Medicinal Chemistry·Ramakanth SarabuJoseph Grimsby
Aug 21, 2012·Bioorganic & Medicinal Chemistry·Letizia PuleoTiziano Croci


Mar 13, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wentong CuiDali Luo
Nov 12, 2014·Postgraduate Medicine·Malcolm A YoungRickey R Reinhardt
Sep 25, 2014·Expert Opinion on Investigational Drugs·Maka S Hedrington, Stephen N Davis
Jul 24, 2014·Expert Opinion on Drug Discovery·Xing XuXu Shen
Jan 12, 2013·Trends in Pharmacological Sciences·Franz M Matschinsky
Aug 22, 2014·Cardiovascular Diabetology·Camille MarciniakSteve Lancel
Apr 17, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·K Swaminathan
Jun 24, 2015·Drug Discovery Today·Abdul AhadFahad I Al-Jenoobi
Dec 18, 2014·The Biochemical Journal·Xiao LuoMing-Wei Wang
Jun 13, 2015·Journal of Diabetes Research·Stephanie Toth-Manikowski, Mohamed G Atta
Dec 3, 2014·Biochimica Et Biophysica Acta·Tomasz Szkudelski, Katarzyna Szkudelska
Aug 1, 2015·PloS One·Gaël EnnequinPascal Sirvent
Oct 17, 2016·Life Sciences·P Sneha, C George Priya Doss
Jan 21, 2017·International Journal of Molecular Sciences·Anca StanaBrînduşa Tiperciuc
Oct 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui LiuHao Wu
Feb 15, 2019·Advanced Healthcare Materials·Anastasia K Varanko, Ashutosh Chilkoti
Mar 6, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Pragya TiwariKhurshid Ahmad
Feb 5, 2020·Molecular Nutrition & Food Research·Céline MoensLuc Bouwens
Jul 23, 2020·Drug Delivery and Translational Research·Rabinarayan Parhi, Aishwarya Mandru
Dec 13, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yanmei Jia, Lirong Chen

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Central Pontine Myelinolysis

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Trichotillomania is an impulse control disorder characterized by the recurrent pulling of one's hair resulting in noticeable hair loss. Here are the latest discoveries in this field.

DDX3X Syndrome

DDX3X syndrome is caused by a spontaneous mutation at conception that primarily affects females due to its location on the X-chromosome. DDX3X syndrome has been linked to intellectual disabilities, seizures, autism, low muscle tone, brain abnormalities, and slower physical developments. Here is the latest research.