Novel phase separated polycaprolactone/collagen scaffolds for cartilage tissue engineering

Biomedical Materials
N Munir, A Callanan

Abstract

Osteoarthritis is the leading cause of pain and disability worldwide. Despite treatment availability, fully functional and suitable long term treatments for large cartilage defects are yet to be sought. Cartilage tissue engineering provides an alternative treatment option with the potential of cartilage regeneration. Previously, scaffolds have been enhanced through coating with collagen type I, however, equal distribution of collagen and collagen penetration throughout the scaffold have been poor. Herein, this study aims to employ thermally induced phase separation to fabricate porous hybrid polycaprolactone (PCL)/collagen type I scaffolds, with equally distributed collagen type I throughout the scaffold. PCL/collagen scaffolds were produced using polycaprolactone, varying concentrations of collagen type I and acetic acid as the solvent. Scaffolds were seeded with chondrocytes for 14 days. Scaffolds possessed an interconnected and porous structure, which altered with an increase in collagen concentration. Collagen type I antibody staining revealed the presence of equally distributed collagen within the PCL fibres. A reduction in collagen type I concentration influenced the compressive properties of the PCL/collagen type 1 scaff...Continue Reading

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Citations

Aug 2, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·James A Reid, Anthony Callanan
Aug 1, 2019·Current Pharmaceutical Biotechnology·Mohammad F Mh Busra, Yogeswaran Lokanathan
Dec 12, 2019·Tissue Engineering and Regenerative Medicine·Do Hyun KimSung Won Kim
Nov 12, 2020·Journal of Tissue Engineering and Regenerative Medicine·Tina NavaeiMasoud Mozafari
Jan 15, 2021·Biomedical Physics & Engineering Express·Alexander Sturtivant, Anthony Callanan
Mar 7, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E MacCraithN F Davis
Apr 9, 2021·International Journal of Pharmaceutics·Amina T Mneimneh, Mohammed M Mehanna
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Aug 29, 2021·Polymers·Ruth NaomiHasnah Bahari
Oct 30, 2021·Tissue Engineering and Regenerative Medicine·Büsra Baskapan, Anthony Callanan

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