Novel phosphate-grafted ePTFE copolymers for optimum in vitro mineralization

Biomedical Materials
Edeline Wentrup-ByrneLisbeth Grøndahl

Abstract

Surface modification via graft copolymerization is an attractive method for optimizing polymers used in biomedical applications. We developed a novel method using a mixed solvent system (either water and dichloromethane (DCM) or water, methanol and DCM) consisting of two solvent phases for grafting 2-(methacryloyloxy)ethyl phosphate onto expanded polytetrafluoroethylene (ePTFE). This new method resulted in the fabrication of grafted membranes with greater grafting extents (GEs) (as evaluated from x-ray photoelectron spectroscopy (XPS)) in the organic phase than those obtained when grafting was carried out in a single phase. It also made it possible to graft in the aqueous phase, a process that is otherwise inhibited by the concomitant formation of large amounts of highly crystalline homopolymer. Thorough characterization of the grafted membranes using gravimetric, XPS and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) not only permitted evaluation of the grafting outcomes but also made it possible to analyze their dependence on monomer concentration and solvent composition. A selection of membranes was tested for their in vitro mineralization capacity using simulated body fluid. It was found tha...Continue Reading

References

Nov 1, 1994·Journal of Biomedical Materials Research·O N TretinnikovY Ikada
May 8, 2003·Journal of Biomedical Materials Research. Part a·Ayako OyaneTakashi Nakamura
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Lisbeth GrøndahlThor Bostrom
Apr 9, 2005·Biomaterials·Shuko SuzukiEdeline Wentrup-Byrne
Nov 14, 2006·Biomacromolecules·Shuko SuzukiEdeline Wentrup-Byrne
Jul 16, 2008·Chemical Communications : Chem Comm·Lisbeth GrøndahlEdeline Wentrup-Byrne

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Citations

Sep 12, 2012·Journal of Biomedical Materials Research. Part a·Adrienne Chandler-TempleLisbeth Grøndahl

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