Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin

Antimicrobial Agents and Chemotherapy
Hongbin SiSiguo Liu

Abstract

A novel nonconjugative plasmid of 28,489 bp from a porcine linezolid-resistant Enterococcus faecium isolate was completely sequenced. This plasmid harbored a novel type of multiresistance gene cluster that comprised the resistance genes lnu(B), lsa(E), spw, aadE, aphA3, and two copies of erm(B), which account for resistance to macrolides, lincosamides, streptogramins, pleuromutilins, streptomycin, spectinomycin, and kanamycin/neomycin. Structural comparisons suggested that this plasmid might have developed from other enterococcal plasmids by insertion element (IS)-mediated interplasmid recombination processes.

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Citations

Oct 24, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mohamed O Ahmed, Keith E Baptiste
Oct 31, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marta DecBarbara Turchi
Jan 24, 2020·The Journal of Antimicrobial Chemotherapy·He YanXiang-Dang Du
Nov 3, 2016·Cold Spring Harbor Perspectives in Medicine·Stefan SchwarzBirte Vester
Sep 22, 2017·Gut Pathogens·Marta DecAndrzej Wernicki
Jun 25, 2017·The Journal of Antimicrobial Chemotherapy·Laura Di SanteFrancesca Biavasco
Oct 31, 2018·BMC Microbiology·Marta DecRenata Urban-Chmiel
Jul 28, 2018·Microbiology Spectrum·Carmen TorresTeresa M Coque

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