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Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry

Jan 1, 2015

Grazia Raffaella TundoStefano Marini

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Abstract

The properties of three novel Platinum(II) compounds toward the insulin-degrading enzyme (IDE) enzymatic activity have been investigated under physiological conditions. The rationale of this study resides on previous observations that these compounds, specifically designed and synthesiz...read more

Mentioned in this Paper

Apoptosis, Intrinsic Pathway
Peripheral T-Cell Lymphoma
Antineoplastic Agents
Insulinase
Cell Death
Dye Exclusion Assays, Antitumor
Tumor Cells, Malignant
Central Neuroblastoma
Oncogenes
Metabolic Inhibition
Paper Details
References
  • References20
  • Citations2
12

Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry

Jan 1, 2015

Grazia Raffaella TundoStefano Marini

PMID: 25450414

DOI: 10.1007/s00775-014-1217-3

Abstract

The properties of three novel Platinum(II) compounds toward the insulin-degrading enzyme (IDE) enzymatic activity have been investigated under physiological conditions. The rationale of this study resides on previous observations that these compounds, specifically designed and synthesiz...read more

Mentioned in this Paper

Apoptosis, Intrinsic Pathway
Peripheral T-Cell Lymphoma
Antineoplastic Agents
Insulinase
Cell Death

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Paper Details
References
  • References20
  • Citations2
12

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