Novel polymeric nanoparticles targeting the lipopolysaccharides of Pseudomonas aeruginosa

International Journal of Pharmaceutics
Y LongC Li

Abstract

Considering outburst of various infectious diseases globally, nanoparticle assisted targeted drug delivery has emerged as a promising strategy that can enhance the therapeutic efficacy and minimize the undesirable side effects of an antimicrobial agents. Molecular imprinting is a newly developed strategy that can synthesize a drug carrier with highly stable ligand-like 'cavity', may serve as a new platform of ligand-free targeted drug delivery systems. In this study, we use the amphiphilic lipopolysaccharides, derived from Pseudomonas aeruginosa as imprinting template and obtained an evenly distributed sub-40 nm polymeric nanoparticles by using inverse emulsion method. These molecularly imprinted nanoparticles (MIPNPs) showed specific binding to the lipopolysaccharide as determined by fluorescence polarization and microscale thermophoresis. MIPNPs showed selective recognition of target bacteria as detected by flow cytometry. Additionally, MIPNPs exhibited the in vivo targeting capabilities in both the keratitis model and meningitis model. Moreover, the photosensitizer methylene blue-loaded MIPNPs presented significantly strong inhibition of bacterial Growth, compared to non-imprinted controls for in vitro model of the photodyna...Continue Reading

References

May 1, 1990·Antimicrobial Agents and Chemotherapy·Y H TsaiR E Kessler
Jan 1, 1993·Journal of Periodontal Research·C E ShelburneR A Curry
Feb 18, 1993·Nature·G VlatakisK Mosbach
Sep 2, 1999·Infectious Disease Clinics of North America·U Koedel, H W Pfister
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Silvia BorrelliAlf A. Lindberg
Oct 15, 2003·FEMS Immunology and Medical Microbiology·Anna N KondakovaZygmunt Sidorczyk
Jan 14, 2004·Molecular Imaging·Bradford A MoffatBrian D Ross
Jul 9, 2004·Journal of the American Chemical Society·Johan SvensonIan A Nicholls
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Mar 10, 2006·Angewandte Chemie·Hidekazu NishinoKenneth J Shea
Feb 27, 2008·Biochemical and Biophysical Research Communications·Wei TangRaoul Kopelman
Oct 24, 2008·Journal of the American Chemical Society·Yu HoshinoKenneth J Shea
Sep 25, 2009·Journal of the American Chemical Society·Arnaud CutivetKarsten Haupt
Mar 18, 2011·Molecular Pharmaceutics·Maheshika KuruppuarachchiRoss W Boyle
Apr 12, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ming QinRaoul Kopelman
Feb 11, 2012·The Analyst·Romana SchirhaglRichard N Zare
Mar 24, 2012·Innate Immunity·Baomei ShaoAlan W Varley
May 25, 2012·Journal of Biomedical Materials Research. Part a·Christopher M HofmannRoger E Marchant
Apr 15, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kazuki TajimaHiroshi Goto
Aug 12, 2014·Angewandte Chemie·Xiantao ShenLei Ye

❮ Previous
Next ❯

Citations

Jul 10, 2019·Thorax·Mohammad DoroudianSeamas C Donnelly
Mar 7, 2020·Journal of Separation Science·Hao ZhangYang Chen
Oct 2, 2020·BioTechniques·Zahra El-SchichAnette Gjörloff Wingren
May 20, 2020·Therapeutic Advances in Medical Oncology·Tianqi SuJiannan Li
Oct 21, 2020·Nanoscale·Alina BekmukhametovaAntonio Lauto
Aug 14, 2020·Chemical Reviews·Karsten HauptBernadette Tse Sum Bui

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.