Novel polymorphisms in the bovine beta-lactoglobulin gene and their effects on beta-lactoglobulin protein concentration in milk

Animal Genetics
N A GanaiM H P W Visker

Abstract

The aim of our study was to detect new polymorphisms in the bovine beta-lactoglobulin (beta-LG) gene with significant effects on beta-LG protein concentration. Genomic DNA samples from 22 proven bulls were screened for polymorphisms in the coding and promoter regions of the beta-LG gene. In total, 50 polymorphisms were detected. Two single nucleotide polymorphisms (SNPs) (g.1772G>A and g.3054C>T) lead to amino acid changes and are the causal genetic polymorphisms of beta-LG protein variants A and B. Forty-two polymorphisms were in complete linkage disequilibrium (LD) with beta-LG protein variants A and B. Any of these 42 polymorphisms can be involved in the differential expression of the respective A and B alleles of the beta-LG gene. The eight polymorphisms not in complete LD with beta-LG protein variants A and B and the two polymorphisms causing the amino acid changes were genotyped in a set of 208 cows: 106 animals homozygous for beta-LG protein variant A and 102 animals homozygous for beta-LG protein variant B. Of these eight polymorphisms, six SNPs segregated only within the cows homozygous for beta-LG protein variant A and two SNPs segregated only within the cows homozygous for beta-LG protein variant B. One of the eight ...Continue Reading

References

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Citations

Oct 20, 2011·The Journal of Dairy Research·Francisco Peñagaricano, Hasan Khatib
Apr 29, 2009·Animal Genetics·G C B SchopenM H P W Visker
May 25, 2011·Journal of Dairy Science·G C B SchopenH Bovenhuis
Mar 31, 2012·Journal of Dairy Science·M H P W ViskerH Bovenhuis
Jul 27, 2011·Journal of Dairy Science·M J M RuttenJ A M van Arendonk
Jun 12, 2013·Journal of Dairy Science·R GambraH Khatib
Jan 15, 2018·Journal of Dairy Science·Qiuyu Wang, Henk Bovenhuis
Feb 3, 2018·Scientific Reports·Tim Martin KnutsenSigbjørn Lien
Oct 2, 2020·Genetics, Selection, Evolution : GSE·Thierry TriboutMarie-Pierre Sanchez
Sep 10, 2014·Journal of Dairy Science·E BijlH Bovenhuis
Dec 23, 2014·Journal of Dairy Science·M GlantzV R Gregersen
Feb 23, 2017·Genetics, Selection, Evolution : GSE·Hubert PauschMichael E Goddard
Jul 22, 2021·Genetics, Selection, Evolution : GSE·Kathryn M TipladyMathew D Littlejohn
Nov 30, 2010·Journal of Proteomics·Emøke BendixenIngrid Miller

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