PMID: 11920853Mar 29, 2002Paper

Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia

American Journal of Medical Genetics
Mineko HattoriS Nanko

Abstract

Based on the neurodevelopmental hypothesis in the etiology of schizophrenia, neurotrophic factors may be involved in the pathogenesis of the illness. We searched for polymorphisms in the promoter region of the neurotrophin-3 (NTF3) gene by using denaturing high performance liquid chromatography (DHPLC). Six single nucleotide polymorphisms (SNPs) were found. When these polymorphisms were examined for association with schizophrenia, a weakly significant difference was observed in the genotype distribution of the G/- 3004/A polymorphism between 184 schizophrenics and 185 controls (P < 0.05), although no statistically significant association was detected in a family-based sample of 50 trios (schizophrenics and their parents). With respect to the other polymorphisms, there was no significant association with schizophrenia. The G/- 3004/A polymorphism was in linkage disequilibrium with the CA repeat polymorphism in the first intron of the NTF3 gene. When haplotype-based analysis was performed, an increased frequency of the haplotype containing the G(- 3004) and the "A3" ([CA]23) alleles was observed for the schizophrenics compared to controls. Our results suggest that the G(- 3004)-A3 haplotype has a modest effect of giving susceptib...Continue Reading

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Citations

Jul 21, 2004·Current Psychiatry Reports·Brian H Shirts, Vishwajit Nimgaonkar
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Giuseppe Blasi, Alessandro Bertolino
Apr 19, 2005·Genome Biology·Alexander B Niculescu
Oct 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·S J EvansH Akil
Jan 10, 2012·Journal of Genetics·Yuzhang ZhuYing Liu
Jun 26, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Soo-Churl ChoJung-Woo Son
Aug 25, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chiara Fabbri, Alessandro Serretti
Apr 23, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Alex C ConnerJohannes Thome
Jun 21, 2014·Neuroscience and Biobehavioral Reviews·Błażej MisiakAndrzej Kiejna
Oct 8, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sern-Yih CheahJoanne Voisey
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Cai TangFlorian Lang
Jan 19, 2005·Molecular Psychiatry·F AngelucciA A Mathé
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Sep 15, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·Nuria Durany, Johannes Thome
Aug 21, 2020·Nordic Journal of Psychiatry·Neha KeshriVikas Menon

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