Novel protective effect of manganese against ferrous citrate-induced lipid peroxidation and nigrostriatal neurodegeneration in vivo.

Brain Research
I SzirákiC C Chiueh

Abstract

Earlier studies intranigrally infusing high doses of manganese (50-250 nmol) revealed a reversible oxidative injury to nigrostriatal dopaminergic neurons. In fact, intranigral infusion of lower dose manganese (4.2 nmol) in the present study did not significantly alter dopamine levels in rat striatum. Moreover, manganese completely suppressed both acute lipid peroxidation in substantia nigra and chronic degeneration of the nigrostriatal neurons induced by intranigral infusion of ferrous citrate (4.2 nmol). These in vivo data indicate that low dose manganese is a potent antioxidant which may activate antioxidative defense mechanisms to protect brain neurons against oxidative stress induced by iron complexes.

References

Dec 1, 1992·Archives of Biochemistry and Biophysics·M CoassinA Bindoli
Jan 1, 1992·Free Radical Biology & Medicine·Y Tampo, M Yonaha
Sep 1, 1991·Neurotoxicology and Teratology·A J Daniels, J Abarca
Nov 15, 1988·Brain Research·M ParentiA Groppetti
Nov 1, 1982·Canadian Journal of Physiology and Pharmacology·J DonaldsonF LaBella
Oct 1, 1984·Journal of Bacteriology·S Y PughI Fridovich
Apr 1, 1984·Journal of Neurochemistry·W J Triggs, L J Willmore
Feb 1, 1981·Acta Pharmacologica Et Toxicologica·G S Shukla, S V Chandra

❮ Previous
Next ❯

Citations

Apr 24, 2004·Annals of the New York Academy of Sciences·Diem HaMai, Stephen C Bondy
Jan 6, 2006·International Journal of Toxicology·Celia A DoddBradley G Klein
Jun 18, 2017·Metallomics : Integrated Biometal Science·Qi YeJonghan Kim
Aug 17, 2006·Antioxidants & Redox Signaling·Florent M MartinJeffrey S Friedman
Dec 3, 2008·Journal of Physiology and Biochemistry·A TylickiB Wojcik
Sep 17, 2013·Biological Trace Element Research·Akram EidiShahabeddin Safi
Jul 6, 2000·Journal of Neuroscience Research·J A RothR W Browne
Jan 1, 1997·Free Radical Biology & Medicine·L PackerK Wessel
Sep 15, 2001·Free Radical Biology & Medicine·D HaMaiS C Bondy
Aug 15, 1998·Journal of Chemical Neuroanatomy·K P MohanakumarC C Chiueh
Jun 28, 2002·Free Radical Biology & Medicine·María José Pérez, Arthur I Cederbaum
Jun 24, 2003·Biochemical Pharmacology·Jerome A Roth, Michael D Garrick
Nov 7, 2003·Neurochemistry International·Diem HaMai, Stephen C Bondy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.