Novel quercetin glucosides from Helminthostachys zeylanica root and acceleratory activity of melanin biosynthesis.

Journal of Natural Medicines
Kosei YamauchiIrmanida Batubara

Abstract

Two novel quercetin glucosides, namely 4'-O-β-D-glucopyranosyl-quercetin-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (compound 1) and 4'-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-quercetin-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (compound 2), were isolated from Helminthostachys zeylanica root 50 % EtOH extract. Structural analysis of isolated compounds was achieved mainly by 600 MHz and 800 MHz NMR, UPLC-TOFMS and GC-MS. Of the two quercetin glucosides, compound 1 showed a high melanogenic acceleratory effect, 2.7 times higher than control, at 10 μM concentration in murine B16 melanoma cells, with no cytotoxic effect.

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Nov 18, 2008·Journal of Ethnopharmacology·Lasse SaabyAnna K Jäger
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Citations

Mar 18, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kosei YamauchiTohru Suzuki
Apr 22, 2014·Free Radical Biology & Medicine·Chun-Yu ChenTsong-Long Hwang
Jul 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Chang WuYuan-Shiun Chang
Feb 15, 2018·Journal of Natural Medicines·Kosei Yamauchi, Tohru Mitsunaga
Aug 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao Niu, Haji A Aisa
Sep 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Chang WuYuan-Shiun Chang
Jan 1, 2017·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Hui CaoHenrique D M Coutinho
Feb 9, 2017·Journal of Natural Products·Yu-Ling HuangChien-Chih Chen

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