PMID: 15244375Jul 13, 2004Paper

Novel radioprotectant drugs for sparing radiation-induced damage to the physis

International Journal of Radiation Biology
Timothy A DamronCornelia E Farnum

Abstract

To determine if pentoxifylline, interleukin 1alpha, selenium and misoprostol can minimize damage to physeal longitudinal growth during single radiation dose exposure in an animal model. Eighty-seven weanling Sprague-Dawley rats were randomized into 15 drug/dose groups. All groups received a single 17.5-Gy gamma-irradiation exposure to the right knee, the left limb serving as an internal control. Pentoxifylline was injected 30 min before exposure, sodium selenite and interleukin 1alpha 24 h before exposure and misoprostol 2 h before exposure. Positive controls received 17.5 Gy. At 6 weeks, animals were sacrificed, the hind limb lengths were measured and detailed histomorphometric analysis was performed. Statistically significant reductions (p < or = 0.03) in mean limb length discrepancy compared with irradiation alone were seen following administration of pentoxifylline (50 mg kg(-1)), interleukin 1alpha (15 mcg kg(-1)), selenium (5 mg kg(-1)) and misoprostol (20 mg kg(-1)). Histomorphometric endpoints and growth rate remained altered at 6 weeks despite treatment, but length discrepancy reduction was highly correlated with the appearance of regenerative clones. Each drug reduced the amount of anticipated growth arrest in the ani...Continue Reading

References

Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P J EifelS L Tucker
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M W DionB Anderson
May 1, 1989·Immunology Letters·M IwamotoY Kato
Jan 1, 1987·Free Radical Research Communications·J F WeissK S Kumar
Jul 1, 1988·International Journal of Radiation Oncology, Biology, Physics·P J Eifel
Sep 1, 1980·Journal of Microscopy·L M Cruz Orive
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·K J StelzerT W Griffin
Mar 15, 1993·International Journal of Radiation Oncology, Biology, Physics·M Werner-Wasik, H Madoc-Jones
Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J HoranB D Boyan
Jan 9, 1998·International Journal of Radiation Oncology, Biology, Physics·X WangP Okunieff
Apr 30, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R M TamurianJ A Spadaro
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·T A DamronL A Damron
Jul 7, 2001·European Journal of Nuclear Medicine·S KinuyaN Tonami
Jul 28, 2001·American Journal of Clinical Oncology·D T ChuaY C Foo
Jan 1, 1992·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·J F WeissM R Landauer
Oct 5, 2001·American Journal of Clinical Oncology·P OkunieffI Ding
Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Tat Khuen Lee, Ieva Stupans
Jul 10, 2003·The Journal of Bone and Joint Surgery. American Volume·Timothy A DamronCornelia E Farnum

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Citations

Oct 25, 2013·International Journal of Biological Sciences·Liren QianJianming Cai
Sep 19, 2008·Expert Opinion on Drug Metabolism & Toxicology·Loren K Mell, Benjamin Movsas
Jun 27, 2009·International Journal of Radiation Biology·Joseph F Weiss, Michael R Landauer
Jun 2, 2009·International Journal of Radiation Oncology, Biology, Physics·Timothy A DamronJoseph A Spadaro
Oct 18, 2005·Cancer Treatment Reviews·Carsten NiederMichael Molls
Aug 19, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jason A HortonCornelia E Farnum
Oct 2, 2008·Plastic and Reconstructive Surgery·Artur GevorgyanChristopher R Forrest
Oct 4, 2007·The Journal of Craniofacial Surgery·Artur GevorgyanChristopher R Forrest
Feb 2, 2006·International Journal of Radiation Biology·Joseph A SpadaroTimothy A Damron

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