Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.

The Journal of Biological Chemistry
Rut FadóNúria Casals

Abstract

The regulation of AMPA-type receptor (AMPAR) abundance in the postsynaptic membrane is an important mechanism involved in learning and memory formation. Recent data suggest that one of the constituents of the AMPAR complex is carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform located in the endoplasmic reticulum of neurons. Previous results had demonstrated that CPT1C deficiency disrupted spine maturation in hippocampal neurons and impaired spatial learning, but the role of CPT1C in AMPAR physiology had remained mostly unknown. In the present study, we show that CPT1C binds GluA1 and GluA2 and that the three proteins have the same expression profile during neuronal maturation. Moreover, in hippocampal neurons of CPT1C KO mice, AMPAR-mediated miniature excitatory postsynaptic currents and synaptic levels of AMPAR subunits GluA1 and GluA2 are significantly reduced. We show that AMPAR expression is dependent on CPT1C levels because total protein levels of GluA1 and GluA2 are decreased in CPT1C KO neurons and are increased in CPT1C-overexpressing neurons, whereas other synaptic proteins remain unaltered. Notably, mRNA levels of AMPARs remained unchanged in those cultures, indicating that CPT1C is post-transcription...Continue Reading

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Citations

Dec 29, 2015·Progress in Lipid Research·Núria CasalsDolors Serra
Jul 10, 2020·The Journal of Physiology·Yasuhiko MinokoshiShiki Okamoto
Aug 24, 2018·Frontiers in Molecular Neuroscience·Esther Gratacòs-BatlleDavid Soto
Apr 3, 2019·Cellular and Molecular Life Sciences : CMLS·Diane BissenAmparo Acker-Palmer
Sep 16, 2020·The Journal of Cell Biology·Maria CasasNúria Casals
Nov 14, 2020·Progress in Lipid Research·Rut FadóNúria Casals
Jan 15, 2021·British Journal of Pharmacology·Cristina MiralpeixRosalía Rodríguez-Rodríguez
Apr 24, 2021·Current Opinion in Pharmacology·Mazyar Abdollahi NejatAugust B Smit
May 2, 2021·Communications Biology·Michael Sloth TrabjergJohn Dirk Vestergaard Nieland
Jul 17, 2021·Neuropharmacology·Peter M MatthewsIngo H Greger
Jun 7, 2019·Neuron·Frank KoopmansMatthijs Verhage

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