Novel regulators and molecular mechanisms of p53R2 and its disease relevance

Biochimie
E C Cho, Yun Yen

Abstract

p53R2 is a p53-inducible human ribonucleotide reductase subunit involved in critical cellular mechanisms, such as DNA repair, cell cycle arrest, and mitochondrial homeostasis. Molecular investigations and animal studies have revealed functional regulations of p53R2 and its disease relevance. The relationship between p53R2 expression and disease progression in different cancers has been evaluated, and researchers have discovered novel transcription factors and cellular mechanisms that control p53R2 in a p53-independent manner. In addition, p53R2-Mediated mechanisms that affect mitochondria, inflammation, and cancer have been addressed. The role of p53R2 in mitochondria diseases and in cancer is discussed. Finally, p53R2 is taken as a potential target for cancer treatment. This review summarizes the general background, novel regulatory findings, and medical prospect of p53R2.

References

Nov 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·A L GartelA L Tyner
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Do-Sun ByunSung-Gil Chi
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Tsutomu YoshidaIsao Okayasu
Jan 27, 2006·The Journal of Biological Chemistry·Pelle HåkanssonLars Thelander
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hai XuChris Dealwis
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroshi OkumuraTakashi Aikou
Aug 22, 2006·Current Cancer Drug Targets·J ShaoY Yen
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiyong LiuYun Yen
Sep 6, 2007·The Journal of Clinical Investigation·Jana S EatonGerald S Shadel
May 14, 2008·Nitric Oxide : Biology and Chemistry·Olivier GuittetMichel Lepoivre
Sep 2, 2008·Cancer Letters·Xin WangFreidoun Albertioni
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lufen ChangYun Yen
Jan 17, 2009·EMBO Reports·Henna Tyynismaa, Anu Suomalainen
May 15, 2009·Nature Reviews. Cancer·Tarek Abbas, Anindya Dutta
Sep 25, 2009·Nature Reviews. Cancer·Arnold J Levine, Moshe Oren
Jan 11, 2011·Molecular Cancer Therapeutics·Keqiang ZhangYun Yen
Jun 7, 2011·Biochemical and Biophysical Research Communications·Xiaochen WangYun Yen
Aug 21, 2012·Journal of Dermatological Science·Shigeto MatsushitaTakuro Kanekura
Sep 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian D Lehmann, Jennifer A Pietenpol
Oct 31, 2012·Brain : a Journal of Neurology·Robert D S PitceathlyGráinne S Gorman
Dec 4, 2012·Cancers·Tomas RadivoyevitchCharles A Kunos
Dec 25, 2012·Nature Cell Biology·Patricia A J Muller, Karen H Vousden
Sep 17, 2013·Mini Reviews in Medicinal Chemistry·Narayana S H N MoorthyPedro A Fernandes
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Deepti Ahluwalia, Roel M Schaaper
Nov 8, 2013·Cancer Research·Maohua XieXingming Deng
Mar 22, 2014·Cancer Cell·Patricia A J Muller, Karen H Vousden
Nov 7, 2014·Frontiers in Oncology·Johanna PflaumMartina Müller

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Citations

Jun 29, 2017·Cell Cycle·Huang BoYanjie Zhang
Jan 18, 2018·Antioxidants & Redox Signaling·Petra HeffeterChristian R Kowol
Dec 31, 2017·The FEBS Journal·Natalie NgEster M Hammond
Aug 1, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·T MaiuriR Truant
Aug 12, 2020·Acta Neuropathologica Communications·Kathleen M FarmerRakez Kayed
Nov 20, 2020·Experimental Cell Research·Kristopher MontroseJuha Saarikangas

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