Novel regulators of cardiac inflammation: Matricellular proteins expand their repertoire

Journal of Molecular and Cellular Cardiology
Marieke Rienks, Anna-Pia Papageorgiou

Abstract

More than 20years ago, Paul Bornstein coined the term matricellular protein to describe a group of secreted extracellular matrix proteins with de-adhesive properties. Though this is still true today, this family of proteins is vastly expanding with new emerging functions pushing the boundaries of this classic definition. In the heart, matricellular proteins have been extensively investigated in models of myocardial infarction, pressure overload, viral myocarditis and age-related cardiomyopathy with clear implications during cardiac fibrosis yet their involvement in regulating cardiac inflammation is less established. In this review, we describe our current understanding of the immune activation by damage- or pathogen-associated molecular pattern molecules during cardiac injury making a distinction between sterile versus non-sterile cardiac inflammation, and explain how matricellular proteins influence this crucial pathophysiological response in the heart.

References

May 5, 1997·The Journal of Cell Biology·R A ClarkT A Springer
Feb 27, 1999·Biochemical Society Transactions·V A FadokP M Henson
Oct 9, 1999·The American Journal of Pathology·I MenaJ L Whitton
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F S Jones, P L Jones
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·P Bornstein
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·R A Brekken, E H Sage
Jan 10, 2002·The Journal of Experimental Medicine·Christian TermeerJan Christoph Simon
Mar 26, 2002·Nature Reviews. Immunology·Carl G FigdorGosse J Adema
Aug 16, 2002·Connective Tissue Research·Denis M MedeirosSylvia A McCune
Jun 27, 2003·Current Opinion in Cardiology·Neil E Bowles, Jesus Vallejo
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Jan 22, 2004·Nature Reviews. Genetics·Jeremy N TimmisWilliam Martin
Sep 24, 2004·Reviews in Medical Virology·DeLisa FairweatherNoel R Rose
Mar 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gregory J BrunnJeffrey L Platt
Jun 4, 2005·The Journal of Biological Chemistry·Henry C Hsia, Jean E Schwarzbauer
Jul 19, 2005·The Journal of Clinical Investigation·Liliana SchaeferHermann-Josef Gröne
Oct 29, 2005·Journal of Virology·Xiaoning SiBruce M McManus
Feb 24, 2006·Cell and Tissue Research·M DobaczewskiN G Frangogiannis
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Nov 16, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F WittchenW Poller
May 15, 2007·Cellular and Molecular Life Sciences : CMLS·M T ElolaG A Rabinovich
Jul 10, 2007·The Journal of Biological Chemistry·Feng WuShukti Chakravarti
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Jun 14, 2008·Expert Reviews in Molecular Medicine·Ri-Yao YangFu-Tong Liu
Jul 29, 2008·Connective Tissue Research·Erika Bereczki, Miklós Sántha
Oct 28, 2008·Cytokine & Growth Factor Reviews·Kathryn X Wang, David T Denhardt
Dec 24, 2008·The Journal of Experimental Medicine·Mark W M SchellingsStephane Heymans
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen

❮ Previous
Next ❯

Citations

Jan 19, 2016·Journal of Molecular and Cellular Cardiology·Iñigo Valiente-AlandiBurns C Blaxall
Dec 2, 2015·Journal of Molecular and Cellular Cardiology·Sander van PuttenBoris Hinz
May 15, 2016·Journal of Molecular and Cellular Cardiology·Joost P G Sluijter, Pieter A Doevendans
Nov 13, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Joshua L DeAgueroDawn A Delfín
Apr 14, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hannah J Riley, Amy D Bradshaw
Sep 22, 2017·Nature Reviews. Cardiology·Gene H KimDaniel Burkhoff
Oct 7, 2017·Molecular Medicine Reports·Yang GuXiwen Zhang
Aug 27, 2019·Frontiers in Cell and Developmental Biology·Amanda LeitolisMarco A Stimamiglio
Aug 10, 2020·Current Cardiology Reports·Dhruv MahttaHani Jneid
Mar 20, 2019·Basic Research in Cardiology·Lucas BacmeisterDiana Lindner
Dec 4, 2015·Journal of Molecular and Cellular Cardiology·Samantha A ClarkeJeffrey W Holmes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Cellular and Molecular Life Sciences : CMLS
David D Roberts
Japanese Journal of Medicine
A Matsumori, C Kawai
Matrix Biology : Journal of the International Society for Matrix Biology
Joanne E Murphy-Ullrich, E H Sage
The American Journal of Pathology
J F Woodruff
© 2022 Meta ULC. All rights reserved