Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo

Journal of Cellular Biochemistry
John S AdamsMercedes Gacad


We undertook an investigation of an outbreak of rachitic bone disease in the Emperor Tamarin New World primate colony at the Los Angeles Zoo in the mid-1980s. The disease phenotype resembled that observed in humans with an inactivating mutation of the vitamin D receptor (VDR), hypocalcemia, high 1,25-dihydroxyvitamin D (1,25-(OH)(2)D) levels, and rickets in rapidly growing adolescent primates. In contrast to the human disease, the New World primate VDR was functionally normal in all respects. The proximate cause of vitamin D hormone resistance in New World primates was determined to be the constitutive overexpression of a heterogeneous nuclear ribonucleoprotein in the A family which we coined the vitamin D response element binding protein (VDRE-BP). VDRE-BP competed in trans with the VDR-retinoid X receptor (RXR) for binding to the vitamin D response element. VDRE-BP-legislated resistance to 1,25-(OH)(2)D was antagonized (i.e., compensated) by another set of constitutively overexpressed proteins, the hsp-70-related intracellular vitamin D binding proteins (IDBPs). IDBPs, present but expressed at much lower levels in Old World primates including man, exhibited a high capacity for 25-hydroxylated vitamin D metabolites and functio...Continue Reading


Mar 1, 1991·The Journal of Clinical Investigation·M A Gacad, J S Adams
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J S Adams, M A Gacad
Mar 1, 1984·Scientific American·D Pilbeam
Jan 1, 1993·Annual Review of Biochemistry·G DreyfussC G Burd
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A Gacad, J S Adams
Oct 1, 1996·Molecular Endocrinology·K B HorwitzL Tung
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·E I Christensen, T E Willnow
Jan 1, 1992·American Journal of Primatology·Mercedes A GacadJohn S Adams
Jan 1, 1985·American Journal of Primatology·John S AdamsRobert K Rude

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