Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo

Journal of Cellular Biochemistry
John S AdamsMercedes Gacad

Abstract

We undertook an investigation of an outbreak of rachitic bone disease in the Emperor Tamarin New World primate colony at the Los Angeles Zoo in the mid-1980s. The disease phenotype resembled that observed in humans with an inactivating mutation of the vitamin D receptor (VDR), hypocalcemia, high 1,25-dihydroxyvitamin D (1,25-(OH)(2)D) levels, and rickets in rapidly growing adolescent primates. In contrast to the human disease, the New World primate VDR was functionally normal in all respects. The proximate cause of vitamin D hormone resistance in New World primates was determined to be the constitutive overexpression of a heterogeneous nuclear ribonucleoprotein in the A family which we coined the vitamin D response element binding protein (VDRE-BP). VDRE-BP competed in trans with the VDR-retinoid X receptor (RXR) for binding to the vitamin D response element. VDRE-BP-legislated resistance to 1,25-(OH)(2)D was antagonized (i.e., compensated) by another set of constitutively overexpressed proteins, the hsp-70-related intracellular vitamin D binding proteins (IDBPs). IDBPs, present but expressed at much lower levels in Old World primates including man, exhibited a high capacity for 25-hydroxylated vitamin D metabolites and functio...Continue Reading

References

Mar 1, 1991·The Journal of Clinical Investigation·M A Gacad, J S Adams
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J S Adams, M A Gacad
Mar 1, 1984·Scientific American·D Pilbeam
Jan 1, 1993·Annual Review of Biochemistry·G DreyfussC G Burd
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A Gacad, J S Adams
Oct 1, 1996·Molecular Endocrinology·K B HorwitzL Tung
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·E I Christensen, T E Willnow
Jan 1, 1992·American Journal of Primatology·Mercedes A GacadJohn S Adams
Jan 1, 1985·American Journal of Primatology·John S AdamsRobert K Rude

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Citations

Dec 5, 2008·Nutrition Reviews·Sam Samuel, Michael D Sitrin
May 23, 2008·The Journal of Endocrinology·Rene F ChunMartin Hewison
Jan 1, 2012·Scientifica·Gerald M HigaChristopher Isabella
Dec 24, 2015·Current Hypertension Reports·Marisa Nile MolinaWalter Manucha
Mar 11, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Diana Andrea Fernandes de AbreuFrançois Féron
Oct 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Enrico BaroniDaniele D'Ambrosio
Oct 20, 2012·Journal of Medical Primatology·Danilo Simonini TeixeiraLuiz Claudio G Castro
Sep 17, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ming TongSuzanne M de la Monte
Aug 1, 2015·Cell Stress & Chaperones·Luciana MazzeiWalter Manucha
Jan 10, 2008·Biochemical and Biophysical Research Communications·Giana AngeloRichard J Wood
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Rui ZhouMartin Hewison
May 5, 2004·The Journal of Biological Chemistry·Hong ChenJohn S Adams
Jan 1, 2016·International Journal of Neurology & Brain Disorders·Ming TongSuzanne M de la Monte
May 27, 2008·Nature Reviews. Molecular Cell Biology·Suzanne Eaton
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
Apr 10, 2020·American Journal of Primatology·Anna E GoodroeToni E Ziegler
Nov 12, 2019·Frontiers in Endocrinology·Rene F ChunJohn S Adams
Jan 1, 2012·Expert Review of Endocrinology & Metabolism·Ashlee McMillanGerald M Higa
Dec 7, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Roger Bouillon, Leen Antonio

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