Novel regulatory therapies for prevention of Graft-versus-host disease.

BMC Medicine
Joseph LeventhalSuzanne T Ildstad

Abstract

Graft-versus-host disease is one of the major transplant-related complications in allogeneic hematopoietic stem cell transplantation. Continued efforts have been made to prevent the occurrence of severe graft-versus-host disease by eliminating or suppressing donor-derived effector T cells. Conventional immunosuppression does not adequately prevent graft-versus-host disease, especially in mismatched transplants. Unfortunately, elimination of donor-derived T cells impairs stem cell engraftment, and delays immunologic reconstitution, rendering the recipient susceptible to post-transplant infections and disease relapse, with potentially lethal consequences. In this review, we discuss the role of dynamic immune regulation in controlling graft-versus-host disease, and how cell-based therapies are being developed using regulatory T cells and other tolerogenic cells for the prevention and treatment of graft-versus-host disease. In addition, advances in the design of cytoreductive conditioning regimens to selectively target graft-versus-host disease-inducing donor-derived T cells that have improved the safety of allogeneic stem cell transplantation are reviewed. Finally, we discuss advances in our understanding of the tolerogenic facili...Continue Reading

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Citations

Jun 4, 2015·Bone Marrow Transplantation·N Or-Geva, Y Reisner
Jun 7, 2014·Current Opinion in Organ Transplantation·Noga Or-Geva, Yair Reisner
Mar 21, 2015·Inflammatory Bowel Diseases·Duke GeemTimothy L Denning
Dec 2, 2017·Journal of the American Society of Nephrology : JASN·Lorenzo GallonValeria R Mas

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Methods Mentioned

BETA
biopsies

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Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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