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Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

Genome Medicine

Nov 14, 2019

Na ZhuWilliam C Nichols

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Abstract

Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy, and heart failure. Mutations in bone morphogeneti...read more

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Case-Control Studies
Genes
Genome
Heart Failure
Hemodynamics
Pulmonary Hypertension
Inflammation
Lung Neoplasms
Vascular Diseases
Gamma-glutamyl carboxylase
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Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

Genome Medicine

Nov 14, 2019

Na ZhuWilliam C Nichols

PMID: 31727138

DOI: 10.1186/s13073-019-0685-z

Abstract

Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy, and heart failure. Mutations in bone morphogeneti...read more

Mentioned in this Paper

Case-Control Studies
Genes
Genome
Heart Failure
Hemodynamics
8
9

Related Papers

Paper Details
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