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Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

Genome Medicine

Nov 16, 2019

Na ZhuWilliam C Nichols

Abstract

Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy, and heart failure. Mutations in bone morphogeneti...read more

Mentioned in this Paper

Gamma-glutamyl carboxylase
Developmental Growth Involved in Morphogenesis
Genome
Genes
GGCX
Whole Exome Sequencing
Vibrio sp. s-2
Sequence Analysis
Right Ventricular Hypertrophy
Tissue Kallikrein
9
9
Paper Details
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Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

Genome Medicine

Nov 16, 2019

Na ZhuWilliam C Nichols

PMID: 31727138

DOI: 10.1186/s13073-019-0685-z

Abstract

Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy, and heart failure. Mutations in bone morphogeneti...read more

Mentioned in this Paper

Gamma-glutamyl carboxylase
Developmental Growth Involved in Morphogenesis
Genome
Genes
GGCX
Whole Exome Sequencing
Vibrio sp. s-2
Sequence Analysis
Right Ventricular Hypertrophy
Tissue Kallikrein
9
9
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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