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Novel risk genes and mechanisms implicated by exome sequencing of 2,572 individuals with pulmonary arterial hypertension

bioRxiv

Feb 14, 2019

Na ZhuWlliam C Nichols

Abstract

Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy and heart failure. Mutations in bone morphogenetic...read more

Mentioned in this Paper

Gamma-glutamyl carboxylase
Pulmonary Arterial Hypertension
Genes
Whole Exome Sequencing
Right Ventricular Hypertrophy
Vascular Diseases
Inflammation
Hemodynamics
Skeletal Bone
BMPR2 protein, human
11
1
9
Paper Details
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Novel risk genes and mechanisms implicated by exome sequencing of 2,572 individuals with pulmonary arterial hypertension

bioRxiv

Feb 14, 2019

Na ZhuWlliam C Nichols

DOI: 10.1101/550327

Abstract

Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy and heart failure. Mutations in bone morphogenetic...read more

Mentioned in this Paper

Gamma-glutamyl carboxylase
Pulmonary Arterial Hypertension
Genes
Whole Exome Sequencing
Right Ventricular Hypertrophy
Vascular Diseases
Inflammation
Hemodynamics
Skeletal Bone
BMPR2 protein, human
11
1
9

Similar Papers Found In These Feeds

Pulmonary Hypertension

Pulmonary hypertension results in increased pulmonary arterial pressures and pulmonary vascular resistance, commonly from cardiac and respiratory diseases. As a result of the structural and functional changes, right heart failure can occur, leading to premature death. Here is the latest research on pulmonary hypertension.

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

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Recent advances in pulmonary arterial hypertension

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