Novel role of cPLA(2)alpha in membrane and actin dynamics.

Cellular and Molecular Life Sciences : CMLS
Maarten MoesElsa Regan-Klapisz

Abstract

Actin-directed processes such as membrane ruffling and cell migration are regulated by specific signal transduction pathways that become activated by growth factor receptors. The same signaling pathways that lead to modifications in actin dynamics also activate cPLA(2)alpha. Moreover, arachidonic acid, the product of cPLA(2)alpha activity, is involved in regulation of actin dynamics. Therefore, it was investigated whether cPLA(2)alpha plays a role in actin dynamics, more specifically during growth factor-induced membrane ruffling and cell migration. Upon stimulation of ruffling and cell migration by growth factors, endogenous cPLA(2)alpha and its active phosphorylated form were shown to relocate at protrusions of the cell membrane involved in actin and membrane dynamics. Inhibition of cPLA(2)alpha activity with specific inhibitors blocked growth factor-induced membrane and actin dynamics, suggesting an important role for cPLA(2)alpha in these processes.

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Citations

Aug 13, 2011·Histochemistry and Cell Biology·Maarten J A MoesJohannes Boonstra
Aug 8, 2013·Astrobiology·Qi LiQingsheng Huang
Aug 24, 2010·Journal of the National Cancer Institute·Amanda G LinkousDennis E Hallahan
Aug 29, 2012·Molecular and Cellular Biology·Jing-Ling HoonCheng-Gee Koh
Jul 14, 2012·PloS One·Lionel TcatchoffKirsten Sandvig
Sep 19, 2012·Cellular and Molecular Life Sciences : CMLS·Natalie Porat-ShliomRoberto Weigert
Jan 11, 2011·Journal of Neurochemistry·James C-M LeeGrace Y Sun
Oct 5, 2010·Biochimica Et Biophysica Acta·Carlos EnrichThomas Grewal
Mar 4, 2021·International Journal of Molecular Sciences·Yulong SunZhuo Zuo

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Methods Mentioned

BETA
GTPases
light microscopy
confocal microscopy

Software Mentioned

Leica Image Manager

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