Novel role of human CD4 molecule identified in neurodegeneration

Nature Medicine
M ButtiniL Mucke

Abstract

The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peripheral immune challenges elicited neurodegeneration in hCD4 mice but not in nontransgenic controls. In post-mortem brain tissues from AIDS patients with opportunistic infections, but without typical HIV encephalitis, hCD4 expression correlated with neurodegeneration. We conclude that hCD4 may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.

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Citations

Nov 2, 2005·Neurotoxicity Research·I P EverallE Masliah
Aug 26, 2009·Scandinavian Journal of Immunology·C HoennscheidtM S Staege
Feb 28, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Torbjørn Hansen
Aug 8, 2002·Neuron·Tony Wyss-Coray, Lennart Mucke
Mar 17, 2007·American Journal of Reproductive Immunology : AJRI·Tanya DimovaRayna Georgieva
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G J WiegersJ M Reul
Mar 14, 2001·Journal of Neuropathology and Experimental Neurology·I P EverallE Masliah

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