PMID: 9178728Jun 1, 1997Paper

Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats

The Journal of Laboratory and Clinical Medicine
N HaradaK Takatsuki

Abstract

We investigated the novel role of prostacyclin (PGI2) in gastric mucosal lesion formation induced by stress in rats. Gastric 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) levels were significantly increased 30 minutes after water-immersion restraint stress (WIR). Subcutaneous indomethacin (IM) (5 mg/kg) inhibited this increase but significantly exacerbated gastric mucosal lesion formation in rats subjected to WIR. Although gastric myeloperoxidase (MPO) activity was not increased by WIR, it significantly increased with time after WIR in animals pretreated with IM. NS-398, a selective inhibitor of cyclooxygenase-2, did not inhibit the WIR-induced increase in gastric 6-keto-PGF1alpha. Neither the gastric lesion index nor gastric MPO activity were affected in animals pretreated with NS-398 and subjected to WIR. WIR-induced mucosal lesion formation was significantly inhibited in animals given iloprost, a stable analog of PGI2, and in those with nitrogen mustard-induced leukocytopenia. Iloprost prevented the gastric leukocyte accumulation and exacerbation of gastric mucosal lesions induced by IM in animals subjected to WIR. These IM-induced events also were prevented in animals subjected to WIR with nitrogen mustard-induced leukocy...Continue Reading

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Citations

Apr 24, 1999·Alimentary Pharmacology & Therapeutics·K MurakamiH Okabe
Dec 23, 2006·Journal of Neurotrauma·Naoaki HaradaKenji Okajima
Mar 21, 2002·Critical Care Medicine·Stanislao MorgeraHans-Hellmut Neumayer
Jan 1, 1999·Journal of Clinical Gastroenterology·T ArakawaT Kuroki
Nov 21, 1998·The Journal of Laboratory and Clinical Medicine·W LiuT Irie
Jun 9, 1999·The Journal of Laboratory and Clinical Medicine·H IsobeN Harada
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Naoaki HaradaTakeshi Katsuragi

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