Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

Neuron
L C Schecterson, M Bothwell

Abstract

The results of our in situ hybridization experiments demonstrate that sensory neurons, sympathetic neurons, and motoneurons express brain-derived neurotrophic factor and/or neurotrophin-3 mRNAs during development in mouse. In accordance with previous data, we also find neurotrophins in the targets of sensory neurons (skin) and motoneurons (muscle) and the neurotrophin receptors p75, trkA, and trkB in sensory and sympathetic ganglia. These results suggest that neurotrophins have roles other than being target-derived factors that support neuron survival during developmental cell death (neurotrophic hypothesis), but may be transported in an orthograde fashion in neurons and released from axon terminals. We discuss several novel roles for neurotrophins, including autocrine/paracrine regulation of neuron survival, regulation of Schwann cell activity, and neuron to target signaling.

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Related Concepts

Neurotrophic Tyrosine Kinase Receptor Type 2
Presynaptic Terminals
Mice, Inbred BALB C
Bdnf
Hormone Receptors, Cell Surface
NTRK1 wt Allele
Transcription, Genetic
Neurons
Recombinant Brain-Derived Growth Factors
Brain-Derived Neurotrophic Factor Measurement

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