Novel root canal sealer with dimethylaminohexadecyl methacrylate, nano-silver and nano-calcium phosphate to kill bacteria inside root dentin and increase dentin hardness

Dental Materials : Official Publication of the Academy of Dental Materials
Bashayer H BarasHockin H K Xu

Abstract

Root canal re-infection and weakening of roots are two main challenges in endodontics. The objectives of the study were: (1) to develop a novel root canal sealer containing dimethylaminohexadecyl methacrylate (DMAHDM), nanoparticles of silver (NAg), and nanoparticles of amorphous calcium phosphate (NACP), and (2) to investigate the effects on the physical, anti-biofilm, remineralizing ions, and hardness of human dentin for the first time. Methacrylate-resin dual-cured root canal sealer contained 5% DMAHDM, 0.15% NAg, and NACP at 10%, 20% and 30% mass fractions. The flow, film thickness, and Ca and P ions release were investigated. The effects of NACP on radicular dentin hardness after treatment with sodium hypochlorite (NaOCL) and ethylenediaminetetraacetic acid (EDTA) were assessed. Antibacterial properties were measured against Enterococcus faecalis (E. faecalis)-impregnated dentin blocks; colony-forming units (CFU) and live/dead assays were measured. Incorporating DMAHDM, NAg and NACP did not adversely influence the flow and film thickness properties. Sealer with 30% NACP neutralized the acid and increased the solution pH (p<0.05). Sealer containing 30% NACP regenerated dentin minerals lost due to NaOCL and EDTA treatment, a...Continue Reading

References

Aug 3, 2001·International Endodontic Journal·R M Love
Aug 23, 2002·International Endodontic Journal·C D Lynch, F M Burke
Aug 31, 2002·Journal of Clinical Microbiology·Ashraf F FouadJustin D Radolf
Oct 26, 2002·Journal of Endodontics·John W DistelM Jane Gillespie
Apr 11, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·Satoshi ImazatoFranklin R Tay
Apr 27, 2004·Journal of Endodontics·Isabela N RôçasKátia R N Santos
Dec 16, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ashraf F FouadLarz S Spångberg
Jun 11, 2005·International Endodontic Journal·G KayaogluD Ørstavik
Jul 27, 2005·Journal of Endodontics·Franklin R TayDavid H Pashley
Jan 24, 2006·Journal of Endodontics·Charles H StuartChristopher B Owatz
Apr 26, 2006·European Journal of Dental Education : Official Journal of the Association for Dental Education in Europe·C D Lynch, F M Burke
Jul 28, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Luciane Dias OliveiraAntonio Olavo Cardoso Jorge
Aug 19, 2007·International Endodontic Journal·M MarendingM Zehnder
Jan 17, 2009·International Dental Journal·Zahed Mohammadi
Feb 23, 2010·Journal of Endodontics·Young Kyung KimFranklin R Tay
May 19, 2010·Journal of Endodontics·Annie ShresthaAnil Kishen
Nov 26, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Jack L Ferracane
Feb 4, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ya-Jun ChengSheng Lin-Gibson
Apr 20, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jennifer L MoreauHockin H K Xu
Apr 26, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Hockin H K XuLaurence C Chow
Nov 1, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Joseph M AntonucciNancy J Lin
Jul 20, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Jack L Ferracane
Feb 14, 2013·Journal of Endodontics·Renata Dornelles MorgentalOve A Peters
Feb 21, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Lei ChengHockin H K Xu
Feb 23, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Fang LiHockin H K Xu
Aug 21, 2013·Journal of Dental Research·F LiH H K Xu
Nov 13, 2013·The Journal of Antimicrobial Chemotherapy·Shaul BeythNurit Beyth
Nov 14, 2013·PloS One·Nurit BeythErvin I Weiss
Nov 21, 2014·Journal of Dental Research·J L Ferracane, W V Giannobile
Feb 11, 2015·International Journal of Biomaterials·Juliana Mattos CorrêaIsis Andréa Venturini Pola Poiate
Mar 17, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·David C Watts
Jul 30, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Jack L Ferracane, Thomas J Hilton
Oct 5, 2016·Journal of Materials Science. Materials in Medicine·Lin WangHockin H K Xu
Dec 4, 2016·Dental Clinics of North America·Ashraf F Fouad
Jun 22, 2017·International Endodontic Journal·H M A AhmedP M H Dummer
Aug 6, 2017·Journal of Endodontics·Maria T P AlbuquerqueMarco C Bottino

❮ Previous
Next ❯

Citations

Nov 27, 2020·Nanomaterials·Oana GherasimAlexandru Mihai Grumezescu
Mar 18, 2021·International Journal of Nanomedicine·Jasmine WongChengfei Zhang
Jul 27, 2021·Advanced Healthcare Materials·Huiliang CaoKlaus D Jandt
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.