Novel S-substituted aminoalkylamino ethanethiols as potential antidotes against sulfur mustard toxicity

Journal of Medicinal Chemistry
U PathakD K Jaiswal

Abstract

Sulfur mustard (SM) is a highly toxic chemical warfare agent. A satisfactory treatment regimen is not yet available for this toxicant. In a search for an effective antidote against SM, a series of novel S-2(omega-aminoalkylamino)ethyl alkyl/aryl thioethers [H(2)N(CH(2))(n)()NHCH(2)CH(2)SR], where R = alky, alicyclic, aryl, and heterocyclic substituents, have been designed and synthesized as candidate antidotes against SM toxicity. These compounds were screened for their protective efficacy through the oral route against dermally applied sulfur mustard in female mice measured on the basis of percent survival following percutaneous administration of SM. A number of compounds demonstrated significant protection.

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Citations

Jul 8, 2010·Indian Journal of Pharmacology·Yangchen Doma BhutiaUma Pathak
Jul 31, 2019·Archiv der Pharmazie·Beatrice SolimanSteffen Pockes
May 10, 2018·Frontiers in Pharmacology·Aastha AroraAnant N Bhatt
Feb 26, 2015·Organic Letters·Cong LinYuhong Zhang
Dec 10, 2016·Journal of Medicinal Chemistry·Vinita ChauhanRam Kumar Dhaked
Feb 5, 2015·Chemical Reviews·Xin ZhouJuyoung Yoon

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