Novel 'schizophrenic' diblock copolymer synthesized via RAFT polymerization: poly(2-succinyloxyethyl methacrylate)-b -poly[(N -4-vinylbenzyl),N ,N -diethylamine

Designed Monomers and Polymers
Aliyeh GhamkhariMehdi Jaymand

Abstract

This article describes the synthesis and characterization of a novel 'schizophrenic' diblock copolymer [poly(2-succinyloxyethyl methacrylate)-b-poly[(N-4-vinylbenzyl),N,N-diethylamine)]; PSEMA-b-PVEA] via reversible addition of fragmentation chain transfer (RAFT) polymerization technique. The chemical structures of all samples as representatives were characterized by means of Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies. The molecular weights of PHEMA and PVEA segments were calculated to be 9770 and 12,630 gmol-1, respectively, from 1H NMR spectroscopy. The self-assembly behavior of the synthesized PSEMA-b-PVEA diblock copolymer was investigated by means of 1H NMR spectroscopy, dynamic light scattering (DLS) measurements, and transmission electron microscopy (TEM) observation. The average sizes of the PSEMA-b-PVEA micelles at pHs 3.0, 6.0, and 10.0 were obtained to be 294, 237, and 201 nm, respectively, from DLS analysis. The zeta potential measurements at various pHs demonstrated that the synthesized PSEMA-b-PVEA diblock copolymer has zwitterionic properties, and the range of isoelectric point's (IEP's) was determined as 5.8-7.3. It is expected that the synthesized PSEMA-b-PVEA dibl...Continue Reading

References

Oct 5, 2013·ACS Applied Materials & Interfaces·Zhe ZhangXuesi Chen

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Citations

Oct 12, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Aliyeh GhamkhariSamira Aghbolaghi
Oct 3, 2020·Biomaterials Science·Mahsa ShahriariMona Alibolandi
Jun 13, 2020·Polymers·Leili MohammadiGeorge Z Kyzas
Jul 25, 2018·Cancers·Nemany A N HanafyStefano Leporatti
Oct 28, 2019·Pharmaceutical Research·Aliyeh GhamkhariReza Rahbarghazi
Feb 18, 2018·Drug Development and Industrial Pharmacy·Nahid PoorgholyHamed Hamishehkar
Dec 20, 2020·International Journal of Biological Macromolecules·Aliyeh GhamkhariMichael R Hamblin
May 6, 2019·International Journal of Biological Macromolecules·Mojtaba AbbasianMehdi Jaymand

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Methods Mentioned

BETA
biosensors
column chromatography
nuclear magnetic resonance
NMR
rheology
RAFT

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