Novel scoring system using cardiopulmonary exercise testing predicts prognosis in heart failure patients receiving guideline-directed medical therapy

Circulation Journal : Official Journal of the Japanese Circulation Society
Teruhiko ImamuraIssei Komuro

Abstract

Among variables obtained from cardiopulmonary exercise testing (CPXT), peak oxygen consumption (PV̇O2) and the minute ventilation vs. carbon dioxide output (V̇E vs. V̇CO2) slope were established as predictors of death of patients with heart failure (HF) at the cutoff points of 14 ml·min(-1)·kg(-1)and 34, respectively. However, a recent update of guideline-directed medical treatment (GDMT) might alter the implication of these variables. We enrolled 77 HF patients receiving GDMT who had undergone symptom-limited CPXT between 2006 and 2014. Among them, 29 patients were re-hospitalized for HF and there were 13 cardiac deaths during the 4-year study period. Cox regression analyses demonstrated that the V̇E vs. V̇CO2slope, peak heart rate, peak systolic blood pressure, and PV̇O2were significant predictors of both re-admission and cardiac death at each cutoff point calculated by receiver-operating characteristic analyses. A new scoring system was constructed using the following criteria: 1 point was assigned to a variable meeting the cutoff point for re-admission; 2 points were assigned to that for cardiac death. The total scores calculated as the summation of each point (range, 0-8 points) had significantly highest area under the cur...Continue Reading

References

Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Jan 1, 1982·Medicine and Science in Sports and Exercise·G A Borg
Jun 1, 1997·Journal of the American College of Cardiology·T P ChuaA J Coats
Jan 18, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Amar L PohwaniGuy A MacGowan
Sep 12, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraMark Barr
Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideki TsurugayaKoichi Taniguchi
Feb 6, 2007·Medicine and Science in Sports and Exercise·Ross A ArenaJoshua Abella
Nov 27, 2008·American Heart Journal·Jonathan MyersMary Ann Peberdy
Mar 9, 2011·Circulation·Peter H Brubaker, Dalane W Kitzman
Jan 17, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruhiko ImamuraMinoru Ono
Apr 4, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruhiko ImamuraIssei Komuro
Apr 22, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Satoshi SaitoUNKNOWN J-MACS Research Group
Jul 11, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruhiko ImamuraIssei Komuro
Aug 19, 2014·Transplantation Proceedings·N FukushimaJ Ashikari

❮ Previous
Next ❯

Citations

Jan 21, 2016·Expert Review of Molecular Diagnostics·Xi ZhangChamindie Punyadeera
May 29, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruhiko ImamuraMinoru Ono
Mar 20, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Teruhiko ImamuraMinoru Ono
Oct 21, 2016·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Teruhiko Imamura, Koichiro Kinugawa
Sep 16, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Damiano MagrìCamillo Autore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.