Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: In-vitro Optimization, Ex-vivo and In-vivo Permeation

Pharmaceutical Research
Wessam M El-RefaieOssama Y Abdallah

Abstract

Hyaluronic acid (HA) is an imperative biomaterial with desirable rheological properties to alleviate symptoms of osteoarthritis. Nevertheless, scantly percutaeous permeation of this macromolecule handicaps its effective use for orthopedics and triggers intra-articular injection as the only surrogate. This study presents novel self-assembeld HA-based gel core elastic nanovesicles, (hyaluosomes; GC-HS), for non-invasive transdermal delivery of HA. GC-HS were prepared with 1% HA using simple film hydration technique. Their size, zeta potential, percentage entrapment efficiency (% EE), elasticity, and ex-vivo transdermal permeation were evaluated compared to conventional liposomes CL. Structure elucidation of the formed novel system was performed using light, polarizing and transmission electron microscopy. In-vivo permeation of GC-HS through knee joints of female Sprague Dawley rats was compared to CL and HA alone. GC-HS showed nanosize (232.8 ± 7.2), high negative zeta potential (-45.1 ± 8.3) and higher elasticity (size alteration 5.43%) compared to CL. This novel system has self-penetration enhancing properties compared to CL and plain gel. GC-HS showed self-assembled properties and high physically stable for at least 6 months a...Continue Reading

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Citations

Jul 21, 2015·International Journal of Pharmaceutics·Heba A HazzahOssama Y Abdallah
Jul 12, 2017·The Open Orthopaedics Journal·Seyit Ali GumustasMahir Mahirogullari
Jan 25, 2019·Pharmaceutical Development and Technology·Dana Kawar, Hamdy Abdelkader
May 8, 2020·Drug Development and Industrial Pharmacy·Lamia Said KandilSherien A Abdelhady
Apr 9, 2021·Progress in Lipid Research·Alexsandra Conceição ApolinárioLuciana Biagini Lopes

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