Novel sesquiterpenoid matrix metalloproteinase-3 inhibitors from an acid mine waste extremophile

Journal of Natural Products
Andrea A StierleKourtney Kemp

Abstract

Berkeley Pit Lake is a 1500 ft deep abandoned open-pit copper mine filled with 30 billion gallons of acidic, metal-contaminated water. This harsh environment is proving to be a source of unusual, biologically active microorganisms. Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of three novel bisabolane sesquiterpenes and a novel coumarin. The isolation and characterization of these compounds are reported here.

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Aug 23, 2003·Journal of Natural Products·Andrea A StierleDanielle Blake

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Citations

Nov 17, 2011·Antonie van Leeuwenhoek·Xueting LiuLixin Zhang
Nov 1, 2007·Journal of Natural Products·Donald B StierleBrianna Patacini
Feb 3, 2012·Journal of Natural Products·Andrea A StierleTeri Girtsman
Jan 27, 2012·Journal of Natural Products·Donald B StierleJesse Nichols
Nov 26, 2008·Natural Product Reports·Danielle Skropeta
Dec 17, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Wei HeXin-Sheng Yao
Feb 23, 2013·Biochimica Et Biophysica Acta·Gordon M Cragg, David J Newman
Mar 12, 2015·Journal of Natural Products·Ling LiuYongsheng Che
Nov 29, 2016·Journal of Asian Natural Products Research·Jian-Hai DingFei Wang
Oct 6, 2010·Natural Product Reports·Elizabeth Jane AshforthLixin Zhang
Apr 21, 2009·Natural Product Reports·Zoe E Wilson, Margaret A Brimble
Feb 6, 2020·Applied Microbiology and Biotechnology·Muhammad IbrarFariha Hasan
Dec 25, 2009·Organic Letters·Jonathan SperryMargaret A Brimble
May 9, 2009·Chemical Reviews·Gordon M CraggDavid J Newman
Mar 12, 2008·Journal of Natural Products·Andrea A StierleBrianna Patacini

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