Novel single nucleotide polymorphism of the VEGF gene as a risk predictor for gastroduodenal ulcers

Journal of Gastroenterology and Hepatology
Yong Seok KimKi Baik Hahm

Abstract

The gastroduodenal ulcer (GDU) mostly develops on the lesser curvature side of stomach and the anterior wall of duodenal bulb, irrespective of the etiologies including Helicobacter pylori infection, non-steroidal anti-inflammatory drugs, alcohol, etc. However, a clear explanation as to why ulcers are prevalent in these areas has still not been given. The current study was designed to evaluate whether the vascular endothelial growth factor (VEGF) polymorphism could predict susceptibility to GDU through deranged angiogenic activities. A large scale case-control study based on known single nucleotide polymorphisms (SNP) of VEGF and another case control study based on the novel SNP of VEGF was performed through the SNP-IT assay using the SNP stream 25 k system. A site-directed mutagenesis and functional assay was executed to document the biological effect of a novel VEGF SNP on angiogenesis. Even though the case-control study between non-ulcer dyspepsia (NUD) and gastric ulcer (GU) patients was done in 10 SNP of the VEGF gene including -2488C/T, -634G/C, -7C/T, 3436G/C, 6112C/A, 6894C/T, 9374G/A, 9812C/T, 13128C/T, and 13553C/T, the analysis showed no statistically significant association between NUD and GU. Denaturing high-perform...Continue Reading

References

Nov 1, 1972·Gastrointestinal Endoscopy·T Miwa, T Sakita
Sep 1, 1971·The British Journal of Surgery·C Piasecki
Apr 12, 2003·Science·Francis S CollinsAristides Patrinos
Apr 16, 2003·Nature·Francis S CollinsUNKNOWN US National Human Genome Research Institute
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 11, 2003·Chest·Seiichiro SakaoTakayuki Kuriyama
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Feb 14, 2004·The Journal of Investigative Dermatology·Helen S YoungChristopher E M Griffiths
Mar 5, 2004·Molecular Human Reproduction·Dimitrios PapazoglouEfstratios Maltezos
May 27, 2004·Investigative Ophthalmology & Visual Science·Richard W I CookeDavid Clark
Apr 12, 2005·Fertility and Sterility·Dimitrios PapazoglouGeorgios B Maroulis
Apr 15, 2005·Mutation Research·Yousin Suh, Jan Vijg
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qianren JinAsta Försti
Jun 7, 2005·Journal of Medical Genetics·W M HowellS Ye
Jul 28, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angela M SummersPaul E C Brenchley
Oct 6, 2005·Molecular Genetics and Metabolism·Kenjiro KosakiTorayuki Okuyama
Mar 2, 2006·Immunogenetics·Roberto Del BoGianpaolo Zerbini
Mar 16, 2006·Breast Cancer Research and Treatment·Lukas A HeflerRobert Zeillinger
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerRobert Zeillinger

❮ Previous
Next ❯

Citations

Aug 29, 2009·Helicobacter·Takahisa Furuta, Jean-Charles Delchier
Aug 6, 2009·Current Opinion in Gastroenterology·Hamed Nayeb-Hashemi, Jonathan D Kaunitz
Sep 6, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vivian Castro Antunes VasconcelosCarmen Silvia Passos Lima
Jul 6, 2021·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Angelo Borsarelli Carvalho BritoCarmen Silvia Passos Lima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.