Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities.

European Journal of Medicinal Chemistry
Gang LiuChunyong Ding

Abstract

The sesquiterpene lactone framework of artemisinin was used as a drug repositioning prototype for the development of novel antitumor drugs. Several series of novel artemisinin analogues (artemalogues) were designed and synthesized through 1,3-dipolar cycloaddition of artemisitene with nitrile oxides or nitrones. The isoxazolidine-containing spirobicyclic artemalogue 11b turns out to be the most potent with low micromolar IC₅₀ values against all three tumor cells, which were at least 4- to 14-fold more potent than the parent artemisinin.

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Citations

Oct 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin ChenXing-Ming Ma
Jan 25, 2019·Current Topics in Medicinal Chemistry·Xiaoyan LiuJingshan Shen
Mar 7, 2020·Acta Crystallographica. Section C, Structural Chemistry·Leonard M KhalilovArthur R Tulyabaev
Feb 19, 2021·European Journal of Medicinal Chemistry·Darshana BoraNagula Shankaraiah
Jun 13, 2019·Organic Letters·Jingming CaoChi-Sing Lee
May 10, 2020·Organic Letters·Dengfeng ChenShenlin Huang
Nov 4, 2021·Organic & Biomolecular Chemistry·Mariia M EfremovaAlexander P Molchanov

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