Novel splice variants of the voltage-sensitive sodium channel alpha subunit

Neuroreport
Y Oh, S G Waxman

Abstract

In this study, we have identified novel splice variants of the Na+ channel alpha subunit mRNA from cultured rat astrocytes and neuroblastoma cells. These splice variants are characterized by premature truncation or deletion of a segment in the third domain of the Na+ channel alpha subunit. The expression of three splice variants was upregulated by exposure to 1 mM dibutyryl cAMP in spinal cord astrocytes but not in cerebral astrocytes and in B50 and B104 neuroblastoma cells. The calcium ionophore 1 microM A23187, did not influence the expression of splice variants in either astrocytes or neuroblastoma cells. These findings suggest that spinal cord astrocytes may maintain a unique regulatory pathway that participates in the control of Na+ channel mRNA expression.

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Citations

Mar 27, 2001·Insect Biochemistry and Molecular Biology·Z LiuK Dong
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May 25, 2021·Epilepsy Currents·Jacy L Wagnon

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