Novel spray freeze-drying technique using four-fluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs

Chemical & Pharmaceutical Bulletin
Toshiyuki NiwaKazumi Danjo

Abstract

Spray freeze-drying (SFD) technique using four-fluid nozzle (4N), which is a novel particle design technique previously developed by authors, has been further developed to expand its application in pharmaceutical industry. The organic solvent was utilized as a spray solvent to dissolve the poorly soluble drug instead of conventional aqueous solution. Acetonitrile solution of the drug and aqueous solution of the polymeric carrier were separately and simultaneously atomized through 4N, and collided each other at the tip of nozzle edge. The spray mists were immediately frozen in the liquid nitrogen to form a suspension. Then, the iced droplets were freeze-dried to prepare the composite particles of the drug and carrier according to our proprietary method developed before. The resultant composite particles with phenytoin prepared by using acetonitrile (4N-SFD-MeCN system) were deeply characterized compared to those using aqueous solution (4N-SFD-aqua system) from morphological and physicochemical perspectives. The characteristic porous structure was observed in 4N-SFD-MeCN particles as well as 4N-SFD-aqua particles. However, it was found that the size and quantity of pore in 4N-SFD-MeCN particles were smaller than those of 4N-SFD-a...Continue Reading

References

Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Feb 1, 1992·The Journal of Allergy and Clinical Immunology·E CalderónD K Ledford
Mar 1, 1988·British Journal of Clinical Pharmacology·R A PrentisS R Walker
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla
Sep 1, 2000·International Journal of Pharmaceutics·W Wang
Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J B Dressman, C Reppas
Mar 22, 2001·Advanced Drug Delivery Reviews·D Hörter, J B Dressman
Mar 29, 2001·Journal of Pharmacological and Toxicological Methods·C A Lipinski
Aug 15, 2002·International Journal of Pharmaceutics·True L RogersRobert O Williams
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Mar 6, 2004·Pharmaceutical Development and Technology·Norbert Rasenack, Bernd W Müller
Mar 23, 2004·Pharmaceutical Research·Robert G Strickley
Sep 2, 2004·Chemical & Pharmaceutical Bulletin·Richer ChenKazumi Danjo
Aug 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tetsuya OzekiHiroaki Okada
Jul 5, 2006·Chemical & Pharmaceutical Bulletin·Richer ChenKazumi Danjo
Jul 14, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Iman Saad Ahmed, Mona Hassan Aboul-Einien
Dec 29, 2007·International Journal of Pharmaceutics·Adchara PongpeerapatKeiji Yamamoto
Apr 21, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Satomi OnoueShizuo Yamada
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sandrien JanssensGuy Van den Mooter
Jul 3, 2009·Chemical & Pharmaceutical Bulletin·Masahiro KondoKazumi Danjo
Aug 19, 2009·International Journal of Pharmaceutics·Toshiyuki NiwaKazumi Danjo

❮ Previous
Next ❯

Citations

Aug 3, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Toshiyuki Niwa, Kazumi Danjo
Mar 29, 2014·Expert Opinion on Drug Delivery·Tarun Garg, Amit K Goyal
Apr 23, 2015·International Journal of Pharmaceutics·Stefan WanningAlf Lamprecht
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Qiyao XiaoDou Zhang
Jul 14, 2012·Chemical & Pharmaceutical Bulletin·Toshiyuki NiwaKazumi Danjo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.