Novel strategies and approaches to develop the next generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV).

Virus Research
Y W Huang, X J Meng

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important swine pathogen. Since its discovery in the early 1990 s, tremendous progresses have been made in understanding the molecular biology and pathogenesis of PRRSV. Although modified live-attenuated vaccines (MLVs) and inactivated vaccines against PRRSV have been available for more than a decade, the disease remains difficult to control. The efficacies of these vaccines especially against heterologous strains remain questionable: the MLVs were generally effective against homologous strains but variable in success against heterologous strains, and the outcomes of inactivated vaccines in the field are not very promising. With the development of PRRSV reverse genetics systems and the acquisition of new understanding on anti-PRRSV immunity, rational design of the next generation of PRRSV vaccines can now be explored. In this review, we discussed the recent advances in anti-PRRSV immunity and vaccinology, the recent progresses in PRRSV vaccine development particularly the reverse genetics system-based vaccine development, and provided a perspective on potential novel strategies and approaches that may be applicable to the development of the next gene...Continue Reading

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Citations

Jan 5, 2014·The Journal of Microbiology·Sang-Im Yun, Young-Min Lee
Dec 14, 2011·Animal Health Research Reviews·Yongming SangFrank Blecha
Jun 22, 2012·Animal Health Research Reviews·Gourapura J RenukaradhyaDavid Benfield
Jan 10, 2012·Transboundary and Emerging Diseases·X J Meng
Feb 26, 2015·The Journal of General Virology·Manreetpal Singh BrarFrederick Chi-Ching Leung
Aug 14, 2013·The Journal of General Virology·Eric J SnijderYing Fang
Jun 1, 2012·Veterinary Immunology and Immunopathology·Gabriela Calzada-NovaFederico A Zuckermann
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Puck B van KasterenMarjolein Kikkert
Jan 1, 2014·Frontiers in Veterinary Science·Massimo Amadori, Elisabetta Razzuoli
Apr 8, 2017·Veterinary Microbiology·Jack DekkersGraham Plastow
Jul 25, 2014·Journal of Virology·Yongming SangFrank Blecha

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Methods Mentioned

BETA
co-immunoprecipitation assay
glycosylation
fluorescent-activated cell sorting
bronchoalveolar
lavage
in vitro transcription
transfection
in-vitro
-transcription
ELISA

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