Novel strategy of sirolimus plus thymalfasin and huaier granule on tumor recurrence of hepatocellular carcinoma beyond the UCSF criteria following liver transplantation: A single center experience

Oncology Letters
Lin ZhouShao-Zhen Yang

Abstract

Although liver transplantation (LT) lengthens the survival time of patients with hepatocellular carcinoma (HCC), LT patients exhibit a high recurrence rate; particularly those that had advanced HCC associated with the tumor biological characteristics and long-term application of immunosuppressants. A consensus on optimal prophylaxis and treatment for recurrent HCC following LT does not currently exist. The present study retrospectively analyzed data from 36 non-University of California at San Francisco criteria-eligible patients with advanced HCC who underwent LT, and then treated them with sirolimus (SRL)-based therapy with thymalfasin and huaier granules (SRL+, n=18), or with tacrolimus-based therapy (controls; n=18). The SRL+ group had significantly longer recurrence times (P=0.008) and survival times (P<0.0001) (OS, 1-year: 100%, 3-year: 94.4%, 5-year: 77.8%; DFS, 1-year: 88.9%, 3-year: 55.6%, 5-year: 50.0%). Furthermore, compared with pre-LT values and the control group, the SRL+ group had significantly lower serum α-fetoprotein (AFP) levels (both P<0.0001) and percentage of Forkhead box P3 (FoxP3)+ Treg lymphocytes (P<0.001) during the first year. In the SRL+ group, FoxP3+/cluster of differentiation (CD)8+ Treg lymphocyte...Continue Reading

References

Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noelia CasaresJuan J Lasarte
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Simone A JoostenTom H M Ottenhoff
May 15, 2007·Annals of the New York Academy of Sciences·Luigina RomaniPaolo Puccetti
Nov 22, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Umberto BaccaraniVittorio Bresadola
Jul 24, 2008·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Nobuhiko TaniaiTakashi Tajiri
Jun 24, 2009·Transplantation Proceedings·M KarczewskiM Glyda
Oct 3, 2009·Journal of Surgical Oncology·Kyung Keun LeeJung Hyun Park
Feb 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian TosoNorman M Kneteman
Apr 21, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Angel E Alsina
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Elke WolfMarkus Horneber
Mar 8, 2011·Gastroenterología y hepatología·José Antonio PonsPascual Parrilla
Sep 3, 2011·Asia-Pacific Journal of Clinical Oncology·Hye Ryun KimHyun Cheol Chung
Sep 21, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlos Gomez-MartinBruno Sangro
Mar 27, 2012·The American Journal of Surgical Pathology·Alka Mary MathaiMatthew M Yeh
Aug 14, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Katharina StauferMartina Sterneck
Aug 17, 2012·Oncology Reports·Xiaolong WangQifeng Yang
Sep 25, 2012·Immunology Letters·Xin ChenZhiming Huang
Oct 11, 2012·Annals of the New York Academy of Sciences·Enrico GaraciPaola Sinibaldi-Vallebona
Oct 12, 2012·Annals of the New York Academy of Sciences·Annalucia SerafinoEnrico Garaci
Feb 15, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jun YanJian Zhou
May 30, 2014·The American Journal of Chinese Medicine·Chao-Yun WangChun-Hua Wang
Nov 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Cong LiJiasheng Zheng
Jun 9, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hui ZhangYao-Sen Wu

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Methods Mentioned

BETA
biopsies
flow cytometry

Software Mentioned

SPSS
SiLIVER

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