Novel stress echocardiographic model incorporating the extent and severity of wall motion abnormality for risk stratification and prognosis

The American Journal of Cardiology
Siu-Sun YaoFarooq A Chaudhry

Abstract

The prognostic value of stress echocardiography to predict future cardiac events using the extent and severity of wall motion abnormalities is not well defined. The objective of this study was to develop and validate a prognostic model for interpretation of stress echocardiographic studies by using the extent and severity of wall motion abnormalities. We evaluated 1,500 patients (59 +/- 13 years old; 51% men) who underwent stress echocardiography (34% on the treadmill exercise and 66% on dobutamine). Left ventricular regional wall motion was assessed by consensus of 2 experienced echocardiographers. Follow-up periods (mean 2.7 +/- 1.0 years) for confirmed myocardial infarction (n = 31) and cardiac death (n = 44) were identified. Multivariate regression analysis identified 2 independent predictors of cardiac events: the number of left ventricular wall segments with new wall motion abnormalities (an index of the extent of ischemia) and the maximal magnitude of new wall motion abnormalities (an index of the severity of ischemia). The ischemic extent (chi-square 48.7, p <0.0001) and maximal severity (chi-square 52.0, p <0.0001) were exponentially correlated with an increase in event rate. On the basis of these data, a prognostic mo...Continue Reading

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Citations

Jan 14, 2010·Annals of Biomedical Engineering·Susan L HerzJeffrey W Holmes
Jun 2, 2009·Cardiovascular Ultrasound·Joselina L M OliveiraAntônio C S Sousa
Jun 18, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Siu-Sun YaoFarooq A Chaudhry
Feb 10, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sripal BangaloreFarooq A Chaudhry
Mar 6, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sripal BangaloreFarooq A Chaudhry
Jul 31, 2007·The American Journal of Cardiology·Sripal BangaloreFarooq A Chaudhry
Oct 25, 2011·The American Journal of Cardiology·Siu-Sun YaoFarooq A Chaudhry
Jan 6, 2015·Echocardiography·Jose Ricardo F PoEdgar Argulian
Sep 25, 2007·Journal of the American College of Cardiology·Sripal BangaloreFarooq A Chaudhry
Jan 16, 2007·Journal of the American College of Cardiology·Louise D MetzKirsten E Fleischmann
Nov 13, 2007·Journal of the American College of Cardiology·Sripal BangaloreFarooq A Chaudhry
Jun 24, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Rajdeep S GaitondeMithilesh K Das
Oct 27, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Edgar ArgulianFarooq A Chaudhry
Aug 11, 2015·Journal of Cardiovascular Medicine·Vikram AgarwalFarooq A Chaudhry
Aug 21, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Pratik MondalDiwakar Jain

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